基于低语廊模式的光学生物传感：超灵敏生物检测与生物成像的发展与应用综述

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-05-28 DOI:10.1016/j.aca.2025.344249

Ruiqi Ming, Jiyang Ma, Ruoyu Zhang, Lili Huang

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引用次数: 0

摘要

近几十年来，基于特定光信号变化的生物检测和生物成像取得了成功。同样，已经出现了大量的策略来提高检测灵敏度。值得注意的是，基于低语画廊模式（WGM）的光学生物传感因其高灵敏度和无标签性而备受关注。在这篇综述中，我们详细介绍了WGM谐振器的表征参数，并阐明了它们与超灵敏生物检测和生物成像的关系。然后，我们提出了WGM谐振器的新兴设计原则和功能化策略。最后，详细介绍了基于wgm的光学生物传感技术在不同生物传感应用中的最新进展。因此，我们的目标是提供新的见解，并激发来自不同领域的研究人员对开发和利用WGM谐振器进行生物传感的兴趣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Whispering-gallery mode-based optical biosensing: A review on development and applications in ultrasensitive biological detection and bioimaging

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Whispering-gallery mode-based optical biosensing: A review on development and applications in ultrasensitive biological detection and bioimaging

Biological detection and bioimaging based on specific optical signal changes have succeeded in recent decades. Likewise, a plethora of strategies have emerged to enhance detection sensitivity. Notably, whispering gallery mode (WGM)-based optical biosensing has attracted significant attention due to its high sensitivity and label-free nature. In this review, we present the characterization parameters of WGM resonators in detail and elucidate their relationship with ultrasensitive biological detection and bioimaging. Then, we present emerging design principles and functionalization strategies of WGM resonators. Finally, we thoroughly describe the recent advances of WGM-based optical biosensing technology in different biosensing applications. Thus, we aim to offer fresh insights and stimulate interest among researchers from various domains toward developing and utilizing WGM resonators for biosensing purposes.

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.