口腔组织球体、类器官和器官芯片微生理建模策略,以增强健康和疾病的模拟

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Z. Gouveia, A. Özkan, W. V. Giannobile, J. P. Santerre, D. T. Wu
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引用次数: 0

摘要

牙科、口腔和颅面(DOC)组织的疾病和失调是全球重大的健康负担,在全球所有报告的疾病中,年龄标准化患病率和发病率最高。虽然已建议应用新疗法来解决不同类型的口腔健康疾病,但仅报道了有限数量的介入性再生疗法来改善临床治疗结果。DOC组织再生缺乏新疗法可能部分归因于从临床前模型到临床试验的高度资源密集型转化路径。最近,利益相关者和监管机构已经开始鼓励使用替代的临床前模型,使用人体组织代替动物模型来测试治疗干预措施。这种倡导可能会为减少或消除动物试验提供机会,最终限制资源支出,并为新的DOC疗法的批准提供更有效的监管途径。虽然传统的2D或3D体外培养模型不能有效地再现DOC生理、缺陷和疾病的复杂性,但更复杂的体外模型(或所谓的微生理系统,包括球体、类器官和器官芯片(OoC)系统)的出现,已经能够有效地模拟几种DOC组织和器官系统的临床模拟疾病状态。在这里,我们的目标是提供这些微生理系统的概述和集体比较,概述它们目前在DOC研究中的应用,并确定它们的利用和能力方面的重要差距,以概括天然口腔颅面生理的基本特征,从而实现针对体内再生结果的新生干预的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oral tissue spheroid, organoid, and organ‐on chip microphysiological modeling strategies towards enhanced emulation of health and disease
Diseases and disorders of dental, oral, and craniofacial (DOC) tissues represent a significant global health burden and have been found to have the greatest age‐standardized prevalence and incidence of all reported diseases worldwide. While the application of novel therapies has been suggested to address the different types of oral health diseases, only a limited number of interventional regenerative therapies have been reported to improve clinical therapeutic outcomes. The lack of novel therapies in DOC tissue regeneration may be in part attributed to the highly resource‐intensive translational path from preclinical models to clinical trials. Recently, stakeholders and regulatory agencies have begun to encourage the use of alternative preclinical models using human tissues for testing therapeutic interventions in place of animal models. This advocacy may provide an opportunity to reduce or eliminate animal testing, ultimately limiting resource expenditure and providing a more efficient regulatory pathway for the approval of novel DOC therapies. While the complexity of DOC physiology, defects, and diseases is not effectively recapitulated in traditional 2D or 3D in vitro culture models, the emergence of more sophisticated in vitro models (or so‐called microphysiological systems that include spheroid, organoid and organ on‐chip (OoC) systems) has enabled effective modeling of clinically simulated disease states in several DOC tissue and organ systems. Here, we aim to provide an overview and collective comparison of these microphysiological systems, outline their current uses in DOC research, and identify important gaps in both their utilization and abilities to recapitulate essential features of native oral‐craniofacial physiology, towards enabling the therapeutic performance of de novo interventions targeted at regeneration outcomes in vivo.
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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