真空冷喷涂法制备磺化聚醚醚酮双功能可生物降解复合涂层:免疫调节驱动骨整合。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Rui Ma, Zidong Wu, Xiaoyu Guo, Zixuan Wu, Zheyue Zhu, Yuning Qu, Kunzheng Wang, Chengxin Li, Kai Ma and Pei Yang
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引用次数: 0

摘要

聚醚醚酮(PEEK)由于其模拟骨模量和生物相容性,是一种很有前途的金属骨科植入物替代品;然而,它的生物惰性往往引发纤维包封,阻碍骨整合。本文采用真空冷喷涂的方法,在磺化PEEK (SP)上制备了可生物降解的硅酸钙/β-磷酸三钙(CS/TCP)复合涂层。CS/TCP涂层表现出强大的结合强度、增强的亲水性和Ca/Si离子的持续释放,促进了磷灰石在模拟体液中的沉积。这种生物活性界面通过极化巨噬细胞向抗炎M2表型促进免疫调节微环境。离子释放和细胞因子分泌协同促进MC3T3-E1细胞粘附、增殖和成骨分化。在体内,CS/TCP-SP降低了大鼠气囊模型的纤维组织厚度,并改善了兔颅骨缺损的骨-种植体整合。可扩展涂层策略将惰性PEEK转化为生物活性,免疫调节植入物,显示出减轻无菌松动和翻修手术的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A dual-functional biodegradable composite coating fabricated on sulfonated PEEK via vacuum cold spraying: immunomodulation-driven osteointegration

A dual-functional biodegradable composite coating fabricated on sulfonated PEEK via vacuum cold spraying: immunomodulation-driven osteointegration

Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) via vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid. This bioactive interface promoted an immunomodulatory microenvironment by polarizing macrophages toward the anti-inflammatory M2 phenotype. Synergistically, ionic release and cytokine secretion enhanced MC3T3-E1 cell adhesion, proliferation, and osteogenic differentiation. In vivo, CS/TCP–SP reduced fibrous tissue thickness in a rat air-pouch model and improved bone–implant integration in rabbit cranial defects. The scalable coating strategy transforms inert PEEK into a bioactive, immunoregulatory implant, demonstrating potential to mitigate aseptic loosening and revision surgeries.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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