Rui Ma, Zidong Wu, Xiaoyu Guo, Zixuan Wu, Zheyue Zhu, Yuning Qu, Kunzheng Wang, Chengxin Li, Kai Ma and Pei Yang
{"title":"真空冷喷涂法制备磺化聚醚醚酮双功能可生物降解复合涂层:免疫调节驱动骨整合。","authors":"Rui Ma, Zidong Wu, Xiaoyu Guo, Zixuan Wu, Zheyue Zhu, Yuning Qu, Kunzheng Wang, Chengxin Li, Kai Ma and Pei Yang","doi":"10.1039/D5TB00628G","DOIUrl":null,"url":null,"abstract":"<p >Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) <em>via</em> vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid. This bioactive interface promoted an immunomodulatory microenvironment by polarizing macrophages toward the anti-inflammatory M2 phenotype. Synergistically, ionic release and cytokine secretion enhanced MC3T3-E1 cell adhesion, proliferation, and osteogenic differentiation. <em>In vivo</em>, CS/TCP–SP reduced fibrous tissue thickness in a rat air-pouch model and improved bone–implant integration in rabbit cranial defects. The scalable coating strategy transforms inert PEEK into a bioactive, immunoregulatory implant, demonstrating potential to mitigate aseptic loosening and revision surgeries.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 24","pages":" 7155-7171"},"PeriodicalIF":6.1000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00628g?page=search","citationCount":"0","resultStr":"{\"title\":\"A dual-functional biodegradable composite coating fabricated on sulfonated PEEK via vacuum cold spraying: immunomodulation-driven osteointegration\",\"authors\":\"Rui Ma, Zidong Wu, Xiaoyu Guo, Zixuan Wu, Zheyue Zhu, Yuning Qu, Kunzheng Wang, Chengxin Li, Kai Ma and Pei Yang\",\"doi\":\"10.1039/D5TB00628G\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) <em>via</em> vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid. This bioactive interface promoted an immunomodulatory microenvironment by polarizing macrophages toward the anti-inflammatory M2 phenotype. Synergistically, ionic release and cytokine secretion enhanced MC3T3-E1 cell adhesion, proliferation, and osteogenic differentiation. <em>In vivo</em>, CS/TCP–SP reduced fibrous tissue thickness in a rat air-pouch model and improved bone–implant integration in rabbit cranial defects. The scalable coating strategy transforms inert PEEK into a bioactive, immunoregulatory implant, demonstrating potential to mitigate aseptic loosening and revision surgeries.</p>\",\"PeriodicalId\":83,\"journal\":{\"name\":\"Journal of Materials Chemistry B\",\"volume\":\" 24\",\"pages\":\" 7155-7171\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00628g?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Chemistry B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb00628g\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb00628g","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
A dual-functional biodegradable composite coating fabricated on sulfonated PEEK via vacuum cold spraying: immunomodulation-driven osteointegration
Polyetheretherketone (PEEK) is a promising orthopedic implant alternative to metals due to its bone-mimetic modulus and biocompatibility; yet, its bioinert nature often triggers fibrous encapsulation and impedes osteointegration. Here, a biodegradable calcium silicate/β-tricalcium phosphate (CS/TCP) composite coating was fabricated on sulfonated PEEK (SP) via vacuum cold spraying to address these limitations. The CS/TCP coating exhibited robust bonding strength, enhanced hydrophilicity, and sustained release of Ca/Si ions, fostering apatite deposition in simulated body fluid. This bioactive interface promoted an immunomodulatory microenvironment by polarizing macrophages toward the anti-inflammatory M2 phenotype. Synergistically, ionic release and cytokine secretion enhanced MC3T3-E1 cell adhesion, proliferation, and osteogenic differentiation. In vivo, CS/TCP–SP reduced fibrous tissue thickness in a rat air-pouch model and improved bone–implant integration in rabbit cranial defects. The scalable coating strategy transforms inert PEEK into a bioactive, immunoregulatory implant, demonstrating potential to mitigate aseptic loosening and revision surgeries.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices