Patryk Sokołowski, Paweł Wityk, Joanna Raczak-Gutknecht, Wiktoria Brzezińska, Michał Sobaszek, Paweł Kalinowski, Sebastian Garcia-Galan, Małgorzata Szczerska
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Optical Method for the Detection of Viral RNA Using an Optical Fiber Sensor
This study introduces a fiber-optic sensor functionalized with a sensing probe for SARS-CoV-2 RNA detection. The sensor employs a microsphere design at the sensor's tip, enhanced with a gold layer and oligonucleotide probes, to achieve high sensitivity and specificity. Utilizing optical interference, the system enables near real-time monitoring of viral RNA at concentrations as low as 10−12 M. While the sensor's sensitivity is lower than that of the RT-PCR, it excels in speed, portability, and scalability, making it suitable for point-of-care diagnostics, environmental monitoring, and large-scale screening. The integration of fiber-optic sensors with advanced analytical systems further enhances their utility in preventing virus transmission and contamination, highlighting their role in global efforts to combat infectious diseases.
期刊介绍：
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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