[姜黄素诱导视网膜荧光增强作为阿尔茨海默病早期诊断的新方法]。

Q3 Medicine
E S Strumentova, V Yu Lobzin, D S Maltsev, M A Burnasheva, T V Sergeeva, A B Buryak
{"title":"[姜黄素诱导视网膜荧光增强作为阿尔茨海默病早期诊断的新方法]。","authors":"E S Strumentova, V Yu Lobzin, D S Maltsev, M A Burnasheva, T V Sergeeva, A B Buryak","doi":"10.17116/jnevro202512504219","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To search for an effective method for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) of amnestic type using scanning laser ophthalmoscopy as a safe and widely available examination method.</p><p><strong>Material and methods: </strong>The study included 45 patients: 20 with AD, 10 with MCI, and 15 healthy control subjects. The patients were examined to visualize amyloid deposition in the retina using a solid lipid food curcumin ligand and a modified scanning laser ophthalmoscope, with a total of 63 observations since not all subjects were eligible for assessment of the retinas of both eyes. All patients underwent a neurological and ophthalmological examination, neuropsychological testing (MMSE, FCSRT, Clock Drawing test), brain MRI for visual assessment of atrophic changes (using global cortical atrophy scales, GCA and the medial temporal lobe atrophy, MTA), as well as confocal scanning laser ophthalmoscopy at two timepoints before and during curcumin administration. A semi-automated calculation of the area increase multiplicity (S) and the number (N) of particles with peak brightness (PPB) was performed.</p><p><strong>Results: </strong>In patients with AD, the following findings were obtained after taking curcumin: N<sub>PPB</sub> 167% [129; 258] (<i>p</i>=0.1) and S<sub>PPB</sub> 198% [148; 230] (<i>p</i>=0.007); MCI: N<sub>PPB</sub> 123% [114; 157] (<i>p</i>=0.15) and S<sub>PPB</sub> 129% [110; 140] (<i>p</i>=0.08).</p><p><strong>Conclusion: </strong>The results indicate an increased deposition of beta-amyloid protein in the retina in patients with AD and expand the possibilities of its early diagnosis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 4. Vyp. 2","pages":"19-25"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Curcumin-induced increased retinal fluorescence as a new method in the early diagnosis of Alzheimer's disease].\",\"authors\":\"E S Strumentova, V Yu Lobzin, D S Maltsev, M A Burnasheva, T V Sergeeva, A B Buryak\",\"doi\":\"10.17116/jnevro202512504219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To search for an effective method for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) of amnestic type using scanning laser ophthalmoscopy as a safe and widely available examination method.</p><p><strong>Material and methods: </strong>The study included 45 patients: 20 with AD, 10 with MCI, and 15 healthy control subjects. The patients were examined to visualize amyloid deposition in the retina using a solid lipid food curcumin ligand and a modified scanning laser ophthalmoscope, with a total of 63 observations since not all subjects were eligible for assessment of the retinas of both eyes. All patients underwent a neurological and ophthalmological examination, neuropsychological testing (MMSE, FCSRT, Clock Drawing test), brain MRI for visual assessment of atrophic changes (using global cortical atrophy scales, GCA and the medial temporal lobe atrophy, MTA), as well as confocal scanning laser ophthalmoscopy at two timepoints before and during curcumin administration. A semi-automated calculation of the area increase multiplicity (S) and the number (N) of particles with peak brightness (PPB) was performed.</p><p><strong>Results: </strong>In patients with AD, the following findings were obtained after taking curcumin: N<sub>PPB</sub> 167% [129; 258] (<i>p</i>=0.1) and S<sub>PPB</sub> 198% [148; 230] (<i>p</i>=0.007); MCI: N<sub>PPB</sub> 123% [114; 157] (<i>p</i>=0.15) and S<sub>PPB</sub> 129% [110; 140] (<i>p</i>=0.08).</p><p><strong>Conclusion: </strong>The results indicate an increased deposition of beta-amyloid protein in the retina in patients with AD and expand the possibilities of its early diagnosis.</p>\",\"PeriodicalId\":56370,\"journal\":{\"name\":\"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova\",\"volume\":\"125 4. Vyp. 2\",\"pages\":\"19-25\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/jnevro202512504219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/jnevro202512504219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

目的:探索一种安全、广泛应用的扫描激光检眼镜早期诊断阿尔茨海默病(AD)和遗忘型轻度认知障碍(MCI)的有效方法。材料和方法:本研究纳入45例患者:AD患者20例,MCI患者10例,健康对照15例。使用固体脂质食物姜黄素配体和改进的扫描激光检眼镜对患者进行了视网膜淀粉样蛋白沉积的可视化检查,由于并非所有受试者都有资格对双眼视网膜进行评估,因此总共进行了63次观察。所有患者在姜黄素给药前和给药期间的两个时间点进行了神经和眼科检查、神经心理测试(MMSE、FCSRT、Clock Drawing test)、脑MRI视觉评估萎缩变化(使用全局皮质萎缩量表、GCA和内侧颞叶萎缩,MTA)以及共聚焦扫描激光检眼镜。对具有峰值亮度的粒子数(PPB)和面积增加倍数(S)进行了半自动化计算。结果:在AD患者中,服用姜黄素后得到以下结果:NPPB 167% [129;258] (p=0.1)和SPPB 198% [148;230) (p = 0.007);MCI: NPPB 123% [114;157] (p=0.15), SPPB为129% [110;140) (p = 0.08)。结论:该结果提示AD患者视网膜β -淀粉样蛋白沉积增加,增加了其早期诊断的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Curcumin-induced increased retinal fluorescence as a new method in the early diagnosis of Alzheimer's disease].

Objective: To search for an effective method for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) of amnestic type using scanning laser ophthalmoscopy as a safe and widely available examination method.

Material and methods: The study included 45 patients: 20 with AD, 10 with MCI, and 15 healthy control subjects. The patients were examined to visualize amyloid deposition in the retina using a solid lipid food curcumin ligand and a modified scanning laser ophthalmoscope, with a total of 63 observations since not all subjects were eligible for assessment of the retinas of both eyes. All patients underwent a neurological and ophthalmological examination, neuropsychological testing (MMSE, FCSRT, Clock Drawing test), brain MRI for visual assessment of atrophic changes (using global cortical atrophy scales, GCA and the medial temporal lobe atrophy, MTA), as well as confocal scanning laser ophthalmoscopy at two timepoints before and during curcumin administration. A semi-automated calculation of the area increase multiplicity (S) and the number (N) of particles with peak brightness (PPB) was performed.

Results: In patients with AD, the following findings were obtained after taking curcumin: NPPB 167% [129; 258] (p=0.1) and SPPB 198% [148; 230] (p=0.007); MCI: NPPB 123% [114; 157] (p=0.15) and SPPB 129% [110; 140] (p=0.08).

Conclusion: The results indicate an increased deposition of beta-amyloid protein in the retina in patients with AD and expand the possibilities of its early diagnosis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.10
自引率
0.00%
发文量
287
审稿时长
3-6 weeks
期刊介绍: Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信