将免疫调节细胞因子编码的mrna传递到网膜：在腹膜转移中将敌人转化为盟友。

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2025-12-01 Epub Date: 2025-05-26 DOI:10.1080/2162402X.2025.2510998

Leire Arrizabalaga, Ignacio Melero, Pedro Berraondo, Fernando Aranda

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引用次数: 0

摘要

由于网膜的免疫抑制特性，腹膜转移仍然是一个重大的临床挑战，而网膜是弥散性肿瘤细胞的保护生态位。我们最近的研究探索了免疫调节细胞因子编码mrna到网膜的靶向递送，旨在将其角色从肿瘤支持部位转变为免疫激活盟友。我们的研究结果强调了细胞因子mRNA递送作为一种新的、安全的腹膜转移免疫治疗策略的潜力。

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Routing immunomodulatory cytokine-encoded mRNAs to the omentum: turning an enemy into an ally in peritoneal metastasis.

Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells. Our recent study explored the targeted delivery of immunomodulatory cytokine-encoded mRNAs to the omentum, aiming to shift its role from a tumor-supportive site to an immune-activating ally. Our findings highlight the potential of cytokine mRNA delivery as a novel and safe immunotherapeutic strategy for peritoneal metastases.

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.