1型糖尿病ß细胞功能障碍的分子和炎症病因。

Physiology (Bethesda, Md.) Pub Date : 2025-05-27 DOI:10.1152/physiol.00008.2025

Cameron R Rostron, Carmella Evans-Molina

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引用次数: 0

摘要

1型糖尿病（T1D）是由自身免疫介导的胰腺β细胞破坏引起的代谢性疾病；然而，最近的研究结果表明，β细胞内的内在应激途径可能有助于自身免疫的启动或延续。在这里，我们讨论了T1D中β细胞功能障碍的分子和炎症病因，重点关注细胞因子信号传导、内质网应激、线粒体功能障碍和衰老。

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Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes.

Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune-mediated destruction of pancreatic β cells; however, recent findings indicate that intrinsic stress pathways within β cells may contribute to the initiation or perpetuation of autoimmunity. Here, we discuss the molecular and inflammatory etiologies of β cell dysfunction in T1D, with a focus on cytokine signaling, endoplasmic reticulum stress, mitochondrial dysfunction, and senescence.

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Physiology (Bethesda, Md.)

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