[溶瘤病毒免疫治疗改善胰腺癌免疫抑制微环境的进展]。

Q4 Medicine

Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-05-01

Kanto Suemori, Hiroshi Tazawa, Motohiko Yamada, Naohiro Okada, Satoru Kikuchi, Shinji Kuroda, Kazuhiro Noma, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara

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引用次数: 0

摘要

胰腺导管腺癌（PDAC）的免疫治疗耐药性限制了治疗结果；因此，改善免疫抑制微环境对PDAC的治疗至关重要。我们开发了一种携带肿瘤抑制基因p53的溶瘤腺病毒OBP-702，并报道了其诱导细胞病变和通过p53诱导激活抗肿瘤免疫的治疗潜力。在本研究中，我们研究了表观遗传调节剂在溶瘤病毒免疫治疗联合树突状细胞疫苗中的治疗潜力。

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本刊更多论文

[Development of Oncolytic Virus Immunotherapy to Improve the Immunosuppressive Microenvironment in Pancreatic Cancer].

Immunotherapy resistance in pancreatic ductal adenocarcinoma(PDAC)limits treatment outcomes; therefore, improving the immunosuppressive microenvironment is important for PDAC treatment. We developed an oncolytic adenovirus, OBP-702, carrying the tumor suppressor gene p53, and report its therapeutic potential to induce cytopathic effects and activate antitumor immunity via p53 induction. In the present study, we investigated the therapeutic potential of epigenetic modulators in oncolytic viral immunotherapy combined with a dendritic cell vaccine.

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来源期刊

Japanese Journal of Cancer and Chemotherapy Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

337