铅暴露对1573名中国男性工人性激素的影响

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2025-05-21 DOI:10.3390/toxics13050415

Ping Wang, Zhiling Wu, Ju Li, Yue Li, Xuefeng Wang, Mengya Ma, Wenkai Wei, Yijun Wang, Yi Liu, Yi Sun, Ling Tao, Yanyan Yang, Ziyuan Zhou, Jingchao Ren, Jia Cao, Guanghui Zhang

{"title":"铅暴露对1573名中国男性工人性激素的影响","authors":"Ping Wang, Zhiling Wu, Ju Li, Yue Li, Xuefeng Wang, Mengya Ma, Wenkai Wei, Yijun Wang, Yi Liu, Yi Sun, Ling Tao, Yanyan Yang, Ziyuan Zhou, Jingchao Ren, Jia Cao, Guanghui Zhang","doi":"10.3390/toxics13050415","DOIUrl":null,"url":null,"abstract":"Lead (Pb) is recognized as an environmental pollutant with male reproductive toxicity, but its effects on sex hormones remain unclear. This study investigated the relationship between male blood lead levels (BLLs) and the sex hormones of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL), as well as testosterone (T), estrogen (E2), and progesterone (PROG). Observational and experimental data from 1573 Pb-exposed workers (712 had also been surveyed in the previous year) and 35 Pb-poisoned patients (before and after Pb chelation therapy) were analyzed. Results from a cross-sectional study showed a nonlinear relationship between BLLs and LH/FSH, and a linear relationship between BLLs and serum T. After Pb chelation therapy, the BLLs in patients decreased from 61.7 to 36.3 (μg/dL), serum T and FSH decreased significantly (p < 0.001), and serum LH also decreased but without a significant change, while PRL and PROG increased significantly (p < 0.01). The data indicate that Pb may disturb male sex hormones by including LH, T, and FSH, and this needs further research.","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 5","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115724/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Lead Exposure on 1573 Male Workers' Sex Hormones in China.\",\"authors\":\"Ping Wang, Zhiling Wu, Ju Li, Yue Li, Xuefeng Wang, Mengya Ma, Wenkai Wei, Yijun Wang, Yi Liu, Yi Sun, Ling Tao, Yanyan Yang, Ziyuan Zhou, Jingchao Ren, Jia Cao, Guanghui Zhang\",\"doi\":\"10.3390/toxics13050415\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lead (Pb) is recognized as an environmental pollutant with male reproductive toxicity, but its effects on sex hormones remain unclear. This study investigated the relationship between male blood lead levels (BLLs) and the sex hormones of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL), as well as testosterone (T), estrogen (E2), and progesterone (PROG). Observational and experimental data from 1573 Pb-exposed workers (712 had also been surveyed in the previous year) and 35 Pb-poisoned patients (before and after Pb chelation therapy) were analyzed. Results from a cross-sectional study showed a nonlinear relationship between BLLs and LH/FSH, and a linear relationship between BLLs and serum T. After Pb chelation therapy, the BLLs in patients decreased from 61.7 to 36.3 (μg/dL), serum T and FSH decreased significantly (p < 0.001), and serum LH also decreased but without a significant change, while PRL and PROG increased significantly (p < 0.01). The data indicate that Pb may disturb male sex hormones by including LH, T, and FSH, and this needs further research.\",\"PeriodicalId\":23195,\"journal\":{\"name\":\"Toxics\",\"volume\":\"13 5\",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12115724/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxics\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.3390/toxics13050415\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxics","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.3390/toxics13050415","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

铅（Pb）是一种公认的具有男性生殖毒性的环境污染物，但其对性激素的影响尚不清楚。本研究探讨了男性血铅水平（BLLs）与黄体生成素（LH）、卵泡刺激素（FSH）、催乳素（PRL）以及睾酮(T)、雌激素（E2）、孕酮（PROG）等性激素的关系。对1573名铅暴露工人（前一年调查了712名）和35名铅中毒患者（铅螯合治疗前后）的观察和实验数据进行了分析。横断研究结果显示，bll与LH/FSH呈非线性关系，bll与血清T呈线性关系。经Pb螯合治疗后，患者bll从61.7降至36.3 (μg/dL)，血清T和FSH显著降低（p < 0.001），血清LH也降低但无显著变化，PRL和PROG显著升高（p < 0.01）。数据表明，Pb可能通过LH、T、FSH等干扰男性性激素，有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of Lead Exposure on 1573 Male Workers' Sex Hormones in China.

Lead (Pb) is recognized as an environmental pollutant with male reproductive toxicity, but its effects on sex hormones remain unclear. This study investigated the relationship between male blood lead levels (BLLs) and the sex hormones of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL), as well as testosterone (T), estrogen (E2), and progesterone (PROG). Observational and experimental data from 1573 Pb-exposed workers (712 had also been surveyed in the previous year) and 35 Pb-poisoned patients (before and after Pb chelation therapy) were analyzed. Results from a cross-sectional study showed a nonlinear relationship between BLLs and LH/FSH, and a linear relationship between BLLs and serum T. After Pb chelation therapy, the BLLs in patients decreased from 61.7 to 36.3 (μg/dL), serum T and FSH decreased significantly (p < 0.001), and serum LH also decreased but without a significant change, while PRL and PROG increased significantly (p < 0.01). The data indicate that Pb may disturb male sex hormones by including LH, T, and FSH, and this needs further research.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.