白葡萄渣对实验性地塞米松所致高血压的有益作用。

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Raluca Maria Pop, Paul-Mihai Boarescu, Corina Ioana Bocsan, Mădălina Luciana Gherman, Veronica Sanda Chedea, Elena-Mihaela Jianu, Ștefan Horia Roșian, Ioana Boarescu, Floricuța Ranga, Maria Doinița Muntean, Maria Comșa, Sebastian Armean, Ana Uifălean, Alina Elena Pârvu, Anca Dana Buzoianu
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引用次数: 0

摘要

背景:葡萄渣(GP)是酿酒的副产品,富含生物活性多酚,具有抗氧化和抗炎特性。虽然红葡萄渣对心血管的益处已经得到了科学的重视,但白葡萄渣的治疗潜力仍未得到充分开发,特别是在糖皮质激素诱导的高血压中。鉴于高血压患病率的上升以及其发展背后的氧化炎症机制,本研究在地塞米松(DEXA)诱导的高血压(HTN)实验模型中研究了白色GP对血压调节、氧化应激和促炎细胞因子表达的影响。通过关注白色GP,本研究解决了当前知识的重大差距,并提出了一种新的、可持续的方法,通过对酿酒副产品进行估价来管理高血压。方法:第一浓度GP1为795 mg多酚/kg bw,第二浓度GP2为397.5 mg多酚/kg bw。结果:DEXA_GP1组白GP多酚提取物具有降低小鼠收缩压和舒张压的作用。多酚(GP1)含量较高的提取物可抑制血清总氧化应激(TOS)、丙二醛(MDA)水平和氧化应激指数(OSI)水平的升高,而多酚(GP2)含量较低的提取物可略微降低血清MDA水平。两组血清NO和总硫醇水平均显著高于赖诺普利组(p < 0.05)。HTN诱导各组血清肿瘤坏死因子-α (TNF-α)水平均升高。两种剂量的GP提取物均可阻止TNF-α的升高。所研究的细胞因子(TNF-α,白细胞介素(IL)-1β和IL-6)的心脏组织水平不受HTN诱导或给予治疗的影响(p > 0.05)。结论:这些发现表明,葡萄渣可能作为一种有希望的营养品干预高血压管理,特别是在与氧化应激相关的条件下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beneficial Effects of White Grape Pomace in Experimental Dexamethasone-Induced Hypertension.

Background: Grape pomace (GP), a by-product of winemaking, is a rich source of bioactive polyphenols known for their antioxidant and anti-inflammatory properties. While the cardiovascular benefits of red grape pomace have received significant scientific attention, the therapeutic potential of white grape pomace remains largely unexplored, particularly in glucocorticoid-induced hypertension. Given the rising prevalence of hypertension and the oxidative-inflammatory mechanisms underlying its progression, this study investigates the effects of white GP on blood pressure regulation, oxidative stress, and pro-inflammatory cytokine expression in an experimental model of dexamethasone (DEXA)-induced hypertension (HTN). By focusing on white GP, this research addresses a significant gap in current knowledge and proposes a novel, sustainable approach to managing hypertension through valorising winemaking by-products.

Methods: The first concentration used, GP1, was 795 mg polyphenols/kg bw, while the second concentration, GP2, was 397.5 mg polyphenols/kg bw.

Results: White GP polyphenols extract in the DEXA_GP1 group had reduced systolic and diastolic blood pressure. The extract with a higher content of polyphenols (GP1) prevented the elevation of serum levels of total oxidative stress (TOS), malondialdehyde (MDA), and oxidative stress index (OSI), while the extract with a lower content of polyphenols (GP2) slightly reduced serum levels of MDA. Both concentrations of GP increased serum levels of NO and Total Thiols, significantly higher (p < 0.05) than in the group treated with lisinopril. The serum levels of tumour necrosis factor-alpha (TNF-α) increased in all groups where HTN was induced. Both doses of GP extract prevented the elevation of TNF-α. Heart tissue levels of the studied cytokines (TNF-α, interleukin (IL)-1β, and IL-6 were not influenced (p > 0.05) by either the HTN induction or the treatment administered.

Conclusions: These findings suggest that grape pomace may serve as a promising nutraceutical intervention for hypertension management, particularly in conditions associated with oxidative stress.

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