细胞外囊泡作为肝癌精准医学的一个有前景的平台。

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-05-24 DOI:10.1016/j.phrs.2025.107800

Keyang Xu, Qibiao Wu, Zhao Lingyun, Romario Nguyen, Fatema Safri, William Yang, Yikun Xu, Yun Ye, Hiu Yee Kwan, Qiang Wang, Xiuming Liang, Muhammad J A Shiddiky, Majid E Warkiani, Jacob George, Jianfeng Bao, Liang Qiao

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引用次数: 0

摘要

细胞外囊泡（EVs）是生物信息的天然载体，在细胞间通讯中起着关键作用。电动汽车具有生物相容性，免疫原性低，能够跨越生物屏障，使其成为疾病诊断和治疗的理想工具。尽管前景光明，但充分实现电动汽车的潜力面临着一些挑战。本文旨在全面综述ev的生物学和分子特性、ev在肝癌中的应用及其可能的机制，以及影响ev治疗肝癌临床转化的关键挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Extracellular vesicles as a promising platform of precision medicine in liver cancer.

Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.