{"title":"低氧调节对中老年人身体健康的影响——系统回顾和荟萃分析。","authors":"Fanji Qiu, Jinfeng Li, Liaoyan Gan","doi":"10.7717/peerj.19348","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hypoxic conditioning has emerged as a promising intervention for enhancing physiological adaptations. This systematic review and meta-analysis of randomized controlled trials aims to investigate the efficacy of hypoxic conditioning on physical fitness measures in aging populations.</p><p><strong>Methods: </strong>The Embase, PubMed, Cochrane Library, and Web of Science were searched from inception to November 2024 (Prospero registration: CRD42023474570). The Cochrane Evaluation Tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework were used for risk of bias assessment and evidence certainty evaluation. Mean differences (MD) and standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using the Review Manager software. Subgroup analysis was performed to explore possible associations between the study characteristics and the effectiveness of the intervention.</p><p><strong>Results: </strong>A total of 13 randomized controlled trials (RCTs) with 368 subjects were included in the meta-analysis. High certainty evidence found hypoxic conditioning (HC) significantly improved peak oxygen uptake (VO<sub>2</sub>peak) (SMD = 0.31, 95% CI [0.01-0.61]; <i>P</i> < 0.05), while very low to moderate certainty evidence shown that hypoxic conditioning (HC) have not induced greater changes on functional outcomes (SMD = -0.21, 95% CI [-0.66-0.24]; <i>P</i> > 0.05), muscle strength (SMD = -0.19, 95% CI [-0.63-0.26]; <i>P</i> > 0.05), maximal power output (SMD = 0.29, 95% CI [-0.17-0.76]; <i>P</i> > 0.05), VO<sub>2</sub>max (SMD = -0.39, 95% CI [-1.12-1.90]; <i>P</i> > 0.05), and exercise workload (MD = -10.07, 95% CI [-34.95-14.80]; <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>This study suggests that hypoxia conditioning has a greater effect on enhancing VO<sub>2</sub>peak compared to equivalent normoxic training in the middle-aged and older population. More high-quality RCTs are needed in the future to explore the optimal oxygen concentration and exercise intensity during hypoxia conditioning.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"13 ","pages":"e19348"},"PeriodicalIF":2.3000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105624/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of hypoxia conditioning on physical fitness in middle-aged and older adults-a systematic review and meta-analysis.\",\"authors\":\"Fanji Qiu, Jinfeng Li, Liaoyan Gan\",\"doi\":\"10.7717/peerj.19348\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hypoxic conditioning has emerged as a promising intervention for enhancing physiological adaptations. This systematic review and meta-analysis of randomized controlled trials aims to investigate the efficacy of hypoxic conditioning on physical fitness measures in aging populations.</p><p><strong>Methods: </strong>The Embase, PubMed, Cochrane Library, and Web of Science were searched from inception to November 2024 (Prospero registration: CRD42023474570). The Cochrane Evaluation Tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework were used for risk of bias assessment and evidence certainty evaluation. Mean differences (MD) and standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using the Review Manager software. Subgroup analysis was performed to explore possible associations between the study characteristics and the effectiveness of the intervention.</p><p><strong>Results: </strong>A total of 13 randomized controlled trials (RCTs) with 368 subjects were included in the meta-analysis. High certainty evidence found hypoxic conditioning (HC) significantly improved peak oxygen uptake (VO<sub>2</sub>peak) (SMD = 0.31, 95% CI [0.01-0.61]; <i>P</i> < 0.05), while very low to moderate certainty evidence shown that hypoxic conditioning (HC) have not induced greater changes on functional outcomes (SMD = -0.21, 95% CI [-0.66-0.24]; <i>P</i> > 0.05), muscle strength (SMD = -0.19, 95% CI [-0.63-0.26]; <i>P</i> > 0.05), maximal power output (SMD = 0.29, 95% CI [-0.17-0.76]; <i>P</i> > 0.05), VO<sub>2</sub>max (SMD = -0.39, 95% CI [-1.12-1.90]; <i>P</i> > 0.05), and exercise workload (MD = -10.07, 95% CI [-34.95-14.80]; <i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>This study suggests that hypoxia conditioning has a greater effect on enhancing VO<sub>2</sub>peak compared to equivalent normoxic training in the middle-aged and older population. More high-quality RCTs are needed in the future to explore the optimal oxygen concentration and exercise intensity during hypoxia conditioning.</p>\",\"PeriodicalId\":19799,\"journal\":{\"name\":\"PeerJ\",\"volume\":\"13 \",\"pages\":\"e19348\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105624/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PeerJ\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.7717/peerj.19348\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PeerJ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.7717/peerj.19348","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：低氧条件已经成为一种很有希望的增强生理适应的干预措施。本研究对随机对照试验进行系统回顾和荟萃分析，旨在探讨低氧条件对老年人体质指标的影响。方法：检索Embase、PubMed、Cochrane Library和Web of Science自成立至2024年11月的数据库（Prospero注册号：CRD42023474570）。采用Cochrane评价工具和分级推荐评估、发展和评价（GRADE）框架进行偏倚风险评估和证据确定性评估。使用Review Manager软件计算平均差异（MD）、标准化平均差异（SMD）和95%置信区间（CI）。进行亚组分析以探索研究特征与干预效果之间可能存在的关联。结果：meta分析共纳入13项随机对照试验（RCTs）， 368名受试者。高确定性证据发现，缺氧条件（HC）显著改善峰值摄氧量（VO2peak） (SMD = 0.31, 95% CI [0.01-0.61]；P P > 0.05),肌肉力量(SMD = -0.19, 95% CI (-0.63 - -0.26);P < 0.05)，最大功率输出(SMD = 0.29, 95% CI [-0.17-0.76]；P > 0.05),的最大摄氧量(SMD = -0.39, 95% CI (-1.12 - -1.90);P < 0.05)，运动负荷(MD = -10.07, 95% CI [-34.95 ~ 14.80]；p > 0.05)。结论：本研究表明，在中老年人群中，与同等的常氧训练相比，低氧条件对提高VO2peak有更大的作用。未来需要更多高质量的随机对照试验来探索低氧条件下的最佳氧浓度和运动强度。
Effect of hypoxia conditioning on physical fitness in middle-aged and older adults-a systematic review and meta-analysis.
Background: Hypoxic conditioning has emerged as a promising intervention for enhancing physiological adaptations. This systematic review and meta-analysis of randomized controlled trials aims to investigate the efficacy of hypoxic conditioning on physical fitness measures in aging populations.
Methods: The Embase, PubMed, Cochrane Library, and Web of Science were searched from inception to November 2024 (Prospero registration: CRD42023474570). The Cochrane Evaluation Tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework were used for risk of bias assessment and evidence certainty evaluation. Mean differences (MD) and standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using the Review Manager software. Subgroup analysis was performed to explore possible associations between the study characteristics and the effectiveness of the intervention.
Results: A total of 13 randomized controlled trials (RCTs) with 368 subjects were included in the meta-analysis. High certainty evidence found hypoxic conditioning (HC) significantly improved peak oxygen uptake (VO2peak) (SMD = 0.31, 95% CI [0.01-0.61]; P < 0.05), while very low to moderate certainty evidence shown that hypoxic conditioning (HC) have not induced greater changes on functional outcomes (SMD = -0.21, 95% CI [-0.66-0.24]; P > 0.05), muscle strength (SMD = -0.19, 95% CI [-0.63-0.26]; P > 0.05), maximal power output (SMD = 0.29, 95% CI [-0.17-0.76]; P > 0.05), VO2max (SMD = -0.39, 95% CI [-1.12-1.90]; P > 0.05), and exercise workload (MD = -10.07, 95% CI [-34.95-14.80]; P > 0.05).
Conclusion: This study suggests that hypoxia conditioning has a greater effect on enhancing VO2peak compared to equivalent normoxic training in the middle-aged and older population. More high-quality RCTs are needed in the future to explore the optimal oxygen concentration and exercise intensity during hypoxia conditioning.
期刊介绍：
PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.
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