通过降低膜张力实现膜电穿孔的快速上升电脉冲。

IF 3.3 4区工程技术 Q2 CHEMISTRY, PHYSICAL

Membranes Pub Date : 2025-05-16 DOI:10.3390/membranes15050151

Ping Ye, Lulu Huang, Kuiwen Zhao

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引用次数: 0

摘要

膜电穿孔是一种新兴的微创消融技术，正在迅速应用于肿瘤和心脏疾病的消融治疗中。不同的电场上升时间导致细胞膜上电场强度的分布和持续时间的变化。本文采用分子动力学模拟方法研究了电场上升时间对膜电穿孔特性的影响。结果表明，快速上升的电脉冲能在短时间内显著降低库仑力引起的膜张力，并导致电场角分布在45°以下有变小的趋势，从而有效地促进了孔隙的形成过程。优化电场上升时间是一种有效的电穿孔消融策略，有可能提高临床肿瘤治疗的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fast-Rising Electric Pulses by Reducing Membrane Tension for Efficient Membrane Electroporation.

Membrane electroporation is an emerging minimally invasive ablation technique being rapidly applied in the ablation treatment of tumors and heart conditions. Different rise times of electric fields lead to variations in the distribution and duration of electric field strength on the cell membrane. This study investigated the effect of the electric field's rise time on membrane electroporation characteristics using molecular dynamics simulations. The results showed that fast-rising electrical pulses can significantly reduce the membrane tension induced by the Coulomb force within a short period of time and lead to a trend of the electric field angle distribution towards smaller values below 45°, thereby effectively promoting the pore formation process. Optimizing the electric field's rise time is an effective electroporation ablation strategy, potentially improving the efficacy of clinical cancer treatment.

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来源期刊

Membranes Chemical Engineering-Filtration and Separation

CiteScore

6.10

自引率

16.70%

发文量

1071

审稿时长

11 weeks

期刊介绍： Membranes (ISSN 2077-0375) is an international, peer-reviewed open access journal of separation science and technology. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.