本科阶段的转化科学:唤醒人才,克服死亡之谷——个案报告。

IF 1.8 3区 医学 Q4 TOXICOLOGY
Rui Seabra Ferreira, Cristina Kampus Mantovani, Ana Silvia Sartori Barraviera Seabra Ferreira, Laura de Oliveira Nascimento, Merari de Fátima Ramires Ferrari, Daniel Fabio Kawano, Katlin Brauer Massirer, Gabriel Forato Anhê, Rosley Anholon, Celso Pereira Caricati, Luciane Meneguin Ortega, Sarah Guilbert, Teresa Lambe, José Paes Oliveira-Filho, Sue Ann Costa Clemens, Benedito Barraviera
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引用次数: 0

摘要

背景:在生物医学领域,转化科学是应用基础科学知识,通过创造新药、设备、医疗程序、预防措施和诊断试剂盒来推进临床研究的过程。2019冠状病毒病大流行暴露出缺乏受过转化研究培训的专业人员,这对应对全球需求至关重要。为了推动进展,研究人员必须克服“死亡之谷”,这是临床研究的一个关键阶段。作为回应,位于巴西博图卡图的圣保罗州立大学(UNESP)的CEVAP发展了一个以转化科学为中心的强大的“知识产业”。作为其研究和创新努力的一部分,CEVAP已经开发了两种生物制药,纤维蛋白密封剂和抗蛇毒血清,目前已进入最后开发阶段。2024年,CEVAP成立了第一个巴西合同开发和制造组织(CDMO),用于开发和生产经过验证和合格的中试规模批次,以生成临床试验材料。案例介绍:翻译科学本科选修课的实施标志着加强“知识产业”的关键一步。该计划是与圣保罗的三所公立大学(USP、UNESP和UNICAMP)合作开发的,还涉及与牛津大学儿科学系和牛津研究小组LATAM的国际伙伴关系。这门课程的成功开设强调了它在跨学科教育和机构合作中的重要性。通过弥合研究与应用之间的差距,该计划使专业人员能够满足对转化科学专业知识日益增长的需求。鉴于该项目的成功,它将转变为一年的“转化科学资格”课程,面向就读于圣保罗州立大学的学生。结论:培养这些专业人员对于将基础研究转化为保健产品、拯救生命和应对未来将在世界各地出现的流行病具有战略意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Translational science at the undergraduate level: awakening talents to overcome the valley of death - case report.

Background: In the biomedical field, translational science is the process of applying basic scientific knowledge to advance clinical research through the creation of new drugs, devices, medical procedures, preventive measures, and diagnostic kits. The Covid-19 pandemic exposed a shortage of professionals trained in translational research, essential for responding to global demands. To drive advancements, researchers must overcome the 'valley of death', a critical phase in clinical investigation. In response, CEVAP at São Paulo State University (UNESP), Botucatu, Brazil, has developed a strong 'knowledge industry' centered on Translational Science. As part of its research and innovation efforts, CEVAP has developed two biopharmaceuticals, the fibrin sealant and the apilic antivenom, which are currently in the final stage of development. In 2024, CEVAP began the first Brazilian Contract Development and Manufacturing Organization (CDMO) for developing and producing validated and qualified pilot-scale batches to generate clinical trial material.

Case presentation: The implementation of the optional undergraduate course in Translational Science marks a crucial step in strengthening the 'knowledge industry'. The program, developed in collaboration with São Paulo's three public universities (USP, UNESP, and UNICAMP), also involves an international partnership with the University of Oxford's Department of Pediatrics and the Oxford Research Group LATAM. The successful launch of this course underscores its importance in interdisciplinary education and institutional collaboration. By bridging gaps between research and application, the program equips professionals to meet the growing demand for expertise in translational science. Given the project's success, it will transition into a one-year 'Qualification in Translational Science', available to students enrolled in São Paulo state universities.

Conclusion: The preparation of these professionals will be strategic for transforming basic research into products for health, saving lives, and combating future pandemics that will emerge around the world.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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