重新定义帕金森病的非运动症状

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Laura Peña-Zelayeta, Karen M Delgado-Minjares, Marcos M Villegas-Rojas, Karen León-Arcia, Alberto Santiago-Balmaseda, Jesús Andrade-Guerrero, Isaac Pérez-Segura, Emmanuel Ortega-Robles, Luis O Soto-Rojas, Oscar Arias-Carrión
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引用次数: 0

摘要

帕金森氏病涉及广泛的神经退行性变,其范围远远超出基底神经节,引起各种各样的非运动症状,这些症状经常在运动发病前出现。这些包括自主神经功能障碍、认知能力下降、神经精神障碍、睡眠相关障碍和感觉缺陷。在这里,我们综合了驱动这些症状的解剖学、神经化学和网络层面机制的现有证据,并研究了它们如何影响疾病进展和临床异质性。我们强调以多巴胺为中心的模型的局限性,并提倡将非运动症状作为障碍的主要机制特征的框架。我们还讨论了新兴技术——如多组学分析、人工智能和网络神经科学——如何使非运动表型的早期识别、分层和精确治疗策略的发展成为可能。认识到非运动症状是帕金森病的核心,重新定义了该疾病的诊断、研究和治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Redefining Non-Motor Symptoms in Parkinson's Disease.

Parkinson's disease involves widespread neurodegeneration that extends far beyond the basal ganglia, giving rise to a diverse range of non-motor symptoms that frequently emerge before motor onset. These include autonomic dysfunction, cognitive decline, neuropsychiatric disturbances, sleep-related disorders, and sensory deficits. Here, we synthesize current evidence on the anatomical, neurochemical, and network-level mechanisms that drive these symptoms, and we examine how they shape disease progression and clinical heterogeneity. We highlight the limitations of dopamine-centric models and advocate for a framework that treats non-motor symptoms as the disorder's primary, mechanistically distinct features. We also discuss how emerging technologies-such as multi-omic profiling, artificial intelligence, and network neuroscience-enable earlier identification, stratification of non-motor phenotypes, and the development of precision-based therapeutic strategies. Recognizing non-motor symptoms as central to Parkinson's disease redefines how the disorder should be diagnosed, studied, and treated.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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