Nicola Manocchio, Carmelo Pirri, Andrea Sorbino, Laura Giordani, Giulia Vita, Concetta Ljoka, Calogero Foti
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The review followed PRISMA guidelines (2020 version), searching PubMed, Web of Science, and SCOPUS. <b>Results:</b> Out of a total of 217 articles, three cohort studies were suitable for our review. Conflicting evidence emerged regarding the association between statins and shoulder tendinopathy from the included papers. The case report describes a patient who experienced RCD after increasing atorvastatin dosage, with symptoms improving after dose reduction and a multimodal personalized IRP. <b>Conclusions:</b> Statins may contribute to tendon injury by altering the extracellular matrix and cell membrane integrity. While tendinopathy and statin relation is still under discussion, clinicians should monitor patients for tendinopathy and consider switching to alternative treatments in case symptoms arise. The case report demonstrated the successful management of statin-induced RCD with a multimodal personalized IRP. Further research is needed to clarify the relationship between statins and shoulder tendinopathy. Early diagnosis and appropriate personalized management are crucial for optimizing patient outcomes.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112834/pdf/","citationCount":"0","resultStr":"{\"title\":\"Shoulder Tendinopathy Induced by Statins: A Case Report and Systematic Review.\",\"authors\":\"Nicola Manocchio, Carmelo Pirri, Andrea Sorbino, Laura Giordani, Giulia Vita, Concetta Ljoka, Calogero Foti\",\"doi\":\"10.3390/jpm15050198\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Statins are essential for managing cholesterol levels but can induce musculoskeletal side effects, including tendinopathy of the shoulder. Rotator Cuff Disease (RCD) is one of the most common shoulder tendinopathy. The aim of the present study is to report a clinical case of statin-induce RCD after performing a systematic review on the subject. <b>Materials and Methods:</b> We performed a systematic review of the literature and report the case of a 49-year-old man with statin-induced RCD treated with a personalized individual rehabilitation project (IRP) (steroid and HA injections, mesotherapy, and therapeutic exercise) to investigate the relationship between statins and shoulder tendinopathy. The review followed PRISMA guidelines (2020 version), searching PubMed, Web of Science, and SCOPUS. <b>Results:</b> Out of a total of 217 articles, three cohort studies were suitable for our review. Conflicting evidence emerged regarding the association between statins and shoulder tendinopathy from the included papers. The case report describes a patient who experienced RCD after increasing atorvastatin dosage, with symptoms improving after dose reduction and a multimodal personalized IRP. <b>Conclusions:</b> Statins may contribute to tendon injury by altering the extracellular matrix and cell membrane integrity. While tendinopathy and statin relation is still under discussion, clinicians should monitor patients for tendinopathy and consider switching to alternative treatments in case symptoms arise. The case report demonstrated the successful management of statin-induced RCD with a multimodal personalized IRP. Further research is needed to clarify the relationship between statins and shoulder tendinopathy. 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引用次数: 0
摘要
背景:他汀类药物对控制胆固醇水平至关重要,但可引起肌肉骨骼副作用,包括肩部肌腱病变。肩袖病(Rotator Cuff Disease, RCD)是最常见的肩部肌腱病变之一。本研究的目的是在对该主题进行系统回顾后报告他汀类药物诱导RCD的临床病例。材料和方法:我们对文献进行了系统的回顾,并报告了一名49岁男性他汀类药物引起的RCD患者接受个性化康复项目(IRP)(类固醇和血凝素注射、化疗和治疗性运动)治疗的病例,以调查他汀类药物与肩部肌腱病变之间的关系。本综述遵循PRISMA指南(2020版),检索PubMed、Web of Science和SCOPUS。结果:在总共217篇文章中,有3篇队列研究适合我们的综述。关于他汀类药物与肩部肌腱病变之间的关系,从纳入的论文中出现了相互矛盾的证据。该病例报告描述了一名患者在增加阿托伐他汀剂量后出现RCD,在减少剂量和多模式个性化IRP后症状改善。结论:他汀类药物可能通过改变细胞外基质和细胞膜完整性而导致肌腱损伤。虽然肌腱病变和他汀类药物的关系仍在讨论中,但临床医生应监测患者的肌腱病变,并考虑在出现症状时改用其他治疗方法。该病例报告展示了通过多模式个性化IRP成功管理他汀类药物诱导的RCD。需要进一步的研究来阐明他汀类药物与肩部肌腱病变之间的关系。早期诊断和适当的个性化管理对于优化患者预后至关重要。
Shoulder Tendinopathy Induced by Statins: A Case Report and Systematic Review.
Background: Statins are essential for managing cholesterol levels but can induce musculoskeletal side effects, including tendinopathy of the shoulder. Rotator Cuff Disease (RCD) is one of the most common shoulder tendinopathy. The aim of the present study is to report a clinical case of statin-induce RCD after performing a systematic review on the subject. Materials and Methods: We performed a systematic review of the literature and report the case of a 49-year-old man with statin-induced RCD treated with a personalized individual rehabilitation project (IRP) (steroid and HA injections, mesotherapy, and therapeutic exercise) to investigate the relationship between statins and shoulder tendinopathy. The review followed PRISMA guidelines (2020 version), searching PubMed, Web of Science, and SCOPUS. Results: Out of a total of 217 articles, three cohort studies were suitable for our review. Conflicting evidence emerged regarding the association between statins and shoulder tendinopathy from the included papers. The case report describes a patient who experienced RCD after increasing atorvastatin dosage, with symptoms improving after dose reduction and a multimodal personalized IRP. Conclusions: Statins may contribute to tendon injury by altering the extracellular matrix and cell membrane integrity. While tendinopathy and statin relation is still under discussion, clinicians should monitor patients for tendinopathy and consider switching to alternative treatments in case symptoms arise. The case report demonstrated the successful management of statin-induced RCD with a multimodal personalized IRP. Further research is needed to clarify the relationship between statins and shoulder tendinopathy. Early diagnosis and appropriate personalized management are crucial for optimizing patient outcomes.
期刊介绍:
Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.