新生儿病毒血症是无症状先天性巨细胞病毒感染母体感染时间的可能预测因子吗?回顾性研究。

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Fabio Natale, Giovanni Boscarino, Giuseppina Liuzzi, Fabrizia Bonci, Giuseppe Maria Albanese, Raffaella Cellitti, Antonella Giancotti, Francesco Franco, Barbara Caravale, Rosaria Turchetta, Ombretta Turriziani, Maria Giulia Conti, Gianluca Terrin
{"title":"新生儿病毒血症是无症状先天性巨细胞病毒感染母体感染时间的可能预测因子吗?回顾性研究。","authors":"Fabio Natale, Giovanni Boscarino, Giuseppina Liuzzi, Fabrizia Bonci, Giuseppe Maria Albanese, Raffaella Cellitti, Antonella Giancotti, Francesco Franco, Barbara Caravale, Rosaria Turchetta, Ombretta Turriziani, Maria Giulia Conti, Gianluca Terrin","doi":"10.3390/jpm15050165","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Asymptomatic congenital cytomegalovirus (acCMV) infections represent 85-90% of all congenital CMV infection. The incidence of late-onset sequelae in these cases significantly contribute to the burden of CMV disease. The timing of maternal infection (TMI) has been identified as the main predictor of late-onset sequelae in acCMV infants, and follow-up programs in Europe are currently calibrated according to the TMI. Our aim was to evaluate neonatal viremia as a possible predictor of the TMI in acCMV infections. <b>Methods:</b> Plasma viral loads (PVLs) were assessed in the first month of life in a population of acCMV-infected newborns delivered by women who suffer a primary CMV infection during pregnancy. TMI was assigned to a trimester of pregnancy according to the maternal serological screening. PVLs were evaluated in relation to the TMI and gestational age (GA) at birth. <b>Results:</b> One hundred and ten newborns were, respectively, assigned to preconceptional (6.4%), 1st (27.3%), 2nd (38.2%), and 3rd (28.2%) trimester infections. Median neonatal PVLs values were significantly different between groups (<i>p</i> < 0.001). First-trimester infections exhibited significantly higher PVLs when compared with third-trimester ones (<i>p</i> < 0.001). Overall, PVLs showed an inverse correlation with GA at birth (<i>p</i> = 0.003). <b>Conclusions:</b> Median neonatal PVLs are significantly higher in 1st trimester infections if compared with 3rd trimester ones, but a wide overlap between PVL values prevent their possible use as a predictor of the TMI. In our population, a significant inverse relationship, mainly dependent on 1st and 2nd trimester infections, is demonstrated between PVLs and GA. Overall, fetal viremia is already decreasing weeks before the term of pregnancy.</p>","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"15 5","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113359/pdf/","citationCount":"0","resultStr":"{\"title\":\"Is Neonatal Viremia a Possible Predictor of the Timing of Maternal Infection in Asymptomatic Congenital Cytomegalovirus Infection? A Retrospective Study.\",\"authors\":\"Fabio Natale, Giovanni Boscarino, Giuseppina Liuzzi, Fabrizia Bonci, Giuseppe Maria Albanese, Raffaella Cellitti, Antonella Giancotti, Francesco Franco, Barbara Caravale, Rosaria Turchetta, Ombretta Turriziani, Maria Giulia Conti, Gianluca Terrin\",\"doi\":\"10.3390/jpm15050165\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Asymptomatic congenital cytomegalovirus (acCMV) infections represent 85-90% of all congenital CMV infection. The incidence of late-onset sequelae in these cases significantly contribute to the burden of CMV disease. The timing of maternal infection (TMI) has been identified as the main predictor of late-onset sequelae in acCMV infants, and follow-up programs in Europe are currently calibrated according to the TMI. Our aim was to evaluate neonatal viremia as a possible predictor of the TMI in acCMV infections. <b>Methods:</b> Plasma viral loads (PVLs) were assessed in the first month of life in a population of acCMV-infected newborns delivered by women who suffer a primary CMV infection during pregnancy. TMI was assigned to a trimester of pregnancy according to the maternal serological screening. PVLs were evaluated in relation to the TMI and gestational age (GA) at birth. <b>Results:</b> One hundred and ten newborns were, respectively, assigned to preconceptional (6.4%), 1st (27.3%), 2nd (38.2%), and 3rd (28.2%) trimester infections. Median neonatal PVLs values were significantly different between groups (<i>p</i> < 0.001). First-trimester infections exhibited significantly higher PVLs when compared with third-trimester ones (<i>p</i> < 0.001). Overall, PVLs showed an inverse correlation with GA at birth (<i>p</i> = 0.003). <b>Conclusions:</b> Median neonatal PVLs are significantly higher in 1st trimester infections if compared with 3rd trimester ones, but a wide overlap between PVL values prevent their possible use as a predictor of the TMI. In our population, a significant inverse relationship, mainly dependent on 1st and 2nd trimester infections, is demonstrated between PVLs and GA. Overall, fetal viremia is already decreasing weeks before the term of pregnancy.</p>\",\"PeriodicalId\":16722,\"journal\":{\"name\":\"Journal of Personalized Medicine\",\"volume\":\"15 5\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113359/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Personalized Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/jpm15050165\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Personalized Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/jpm15050165","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0

摘要

背景:无症状先天性巨细胞病毒(acCMV)感染占所有先天性巨细胞病毒感染的85-90%。在这些病例中,迟发性后遗症的发生率显著增加了巨细胞病毒疾病的负担。母体感染时间(TMI)已被确定为acCMV婴儿迟发性后遗症的主要预测因素,欧洲的随访计划目前根据TMI进行校准。我们的目的是评估新生儿病毒血症作为acCMV感染TMI的可能预测因子。方法:对妊娠期间原发巨细胞病毒感染的妇女所生的感染accmv的新生儿在出生后第一个月的血浆病毒载量(PVLs)进行评估。根据母体血清学筛查,TMI被指定为妊娠三个月。评估pvl与TMI和出生时胎龄(GA)的关系。结果:110例新生儿分别为孕前感染(6.4%)、妊娠1期感染(27.3%)、妊娠2期感染(38.2%)和妊娠3期感染(28.2%)。新生儿pvl中位数组间差异有统计学意义(p < 0.001)。妊娠早期感染的pvl明显高于妊娠晚期感染(p < 0.001)。总体而言,pvl与出生时GA呈负相关(p = 0.003)。结论:与妊娠晚期相比,妊娠早期感染的新生儿PVL中位数明显高于妊娠晚期感染,但PVL值之间的广泛重叠阻止了它们作为TMI预测因子的可能性。在我们的人群中,pvl和GA之间存在显著的反比关系,主要依赖于妊娠第一和妊娠第二阶段的感染。总的来说,胎儿病毒血症在妊娠期前几周就已经在减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is Neonatal Viremia a Possible Predictor of the Timing of Maternal Infection in Asymptomatic Congenital Cytomegalovirus Infection? A Retrospective Study.

Background: Asymptomatic congenital cytomegalovirus (acCMV) infections represent 85-90% of all congenital CMV infection. The incidence of late-onset sequelae in these cases significantly contribute to the burden of CMV disease. The timing of maternal infection (TMI) has been identified as the main predictor of late-onset sequelae in acCMV infants, and follow-up programs in Europe are currently calibrated according to the TMI. Our aim was to evaluate neonatal viremia as a possible predictor of the TMI in acCMV infections. Methods: Plasma viral loads (PVLs) were assessed in the first month of life in a population of acCMV-infected newborns delivered by women who suffer a primary CMV infection during pregnancy. TMI was assigned to a trimester of pregnancy according to the maternal serological screening. PVLs were evaluated in relation to the TMI and gestational age (GA) at birth. Results: One hundred and ten newborns were, respectively, assigned to preconceptional (6.4%), 1st (27.3%), 2nd (38.2%), and 3rd (28.2%) trimester infections. Median neonatal PVLs values were significantly different between groups (p < 0.001). First-trimester infections exhibited significantly higher PVLs when compared with third-trimester ones (p < 0.001). Overall, PVLs showed an inverse correlation with GA at birth (p = 0.003). Conclusions: Median neonatal PVLs are significantly higher in 1st trimester infections if compared with 3rd trimester ones, but a wide overlap between PVL values prevent their possible use as a predictor of the TMI. In our population, a significant inverse relationship, mainly dependent on 1st and 2nd trimester infections, is demonstrated between PVLs and GA. Overall, fetal viremia is already decreasing weeks before the term of pregnancy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信