{"title":"先天性急性髓性白血病1例报告。","authors":"Sondus Alsharidah, Eman Almatar","doi":"10.2147/IMCRJ.S499579","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Congenital acute myeloid leukemia (AML) is a rare but critical hematologic malignancy diagnosed in neonates and associated with a high mortality rate.</p><p><strong>Case presentation: </strong>This report describes a 3-month-old female diagnosed with congenital AML, characterized by mixed lineage leukemia (MLL) gene rearrangement. The patient presented with severe complications, including typhlitis, abscess, seizures, and pericardial effusion.</p><p><strong>Management and outcomes: </strong>Despite the challenges posed by the patient's age and the severity of her condition, she responded well to initial treatment. However, her long-term prognosis remains uncertain. Hematopoietic stem cell transplantation (HSCT) is being considered as part of her ongoing management.</p><p><strong>Conclusion: </strong>Early diagnosis and tailored treatment strategies for congenital AML are crucial. This case underscores the need for continued research to refine treatment protocols aimed at improving survival rates in this vulnerable population.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"18 ","pages":"585-590"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104308/pdf/","citationCount":"0","resultStr":"{\"title\":\"Congenital Acute Myeloid Leukemia (AML): A Case Report.\",\"authors\":\"Sondus Alsharidah, Eman Almatar\",\"doi\":\"10.2147/IMCRJ.S499579\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Congenital acute myeloid leukemia (AML) is a rare but critical hematologic malignancy diagnosed in neonates and associated with a high mortality rate.</p><p><strong>Case presentation: </strong>This report describes a 3-month-old female diagnosed with congenital AML, characterized by mixed lineage leukemia (MLL) gene rearrangement. The patient presented with severe complications, including typhlitis, abscess, seizures, and pericardial effusion.</p><p><strong>Management and outcomes: </strong>Despite the challenges posed by the patient's age and the severity of her condition, she responded well to initial treatment. However, her long-term prognosis remains uncertain. Hematopoietic stem cell transplantation (HSCT) is being considered as part of her ongoing management.</p><p><strong>Conclusion: </strong>Early diagnosis and tailored treatment strategies for congenital AML are crucial. This case underscores the need for continued research to refine treatment protocols aimed at improving survival rates in this vulnerable population.</p>\",\"PeriodicalId\":14337,\"journal\":{\"name\":\"International Medical Case Reports Journal\",\"volume\":\"18 \",\"pages\":\"585-590\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104308/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Medical Case Reports Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/IMCRJ.S499579\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Medical Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/IMCRJ.S499579","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Congenital Acute Myeloid Leukemia (AML): A Case Report.
Background: Congenital acute myeloid leukemia (AML) is a rare but critical hematologic malignancy diagnosed in neonates and associated with a high mortality rate.
Case presentation: This report describes a 3-month-old female diagnosed with congenital AML, characterized by mixed lineage leukemia (MLL) gene rearrangement. The patient presented with severe complications, including typhlitis, abscess, seizures, and pericardial effusion.
Management and outcomes: Despite the challenges posed by the patient's age and the severity of her condition, she responded well to initial treatment. However, her long-term prognosis remains uncertain. Hematopoietic stem cell transplantation (HSCT) is being considered as part of her ongoing management.
Conclusion: Early diagnosis and tailored treatment strategies for congenital AML are crucial. This case underscores the need for continued research to refine treatment protocols aimed at improving survival rates in this vulnerable population.
期刊介绍：
International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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