平衡口服氧化还原状态:内源性和外源性活性氧来源及紫堇科和菊科植物的抗氧化作用。

IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Caterina Nela Dumitru, Lupoae Mariana, Cristian Constantin Budacu, Gabriela Mitea, Marius Daniel Radu, Alina Oana Dumitru, Andreea Lupoae, Alin Tatu, Gabi Topor
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引用次数: 0

摘要

背景/目的:口腔健康是一个复杂的概念,涉及生理、心理、情感和社会因素。维持口腔组织完整性的一个关键因素是氧化还原平衡,氧化应激(OS)通过活性氧(ROS)和抗氧化防御之间的不平衡破坏了氧化还原平衡。本研究探讨了内源和外源对氧化还原的贡献,并探讨了菊科和兰科药用植物在恢复氧化还原稳态和改善口腔健康方面的治疗潜力。方法:通过文献综述,分析菊科植物中OS在口腔疾病中的作用及抗氧化作用机制。特别关注了它们的植物化学成分——多酚、类黄酮和精油——以及它们与口腔健康的生物学相关性。结果:OS在龋齿、牙周炎、牙龈炎、口腔溃疡、脓肿、癌前病变和口腔癌等口腔疾病的发生和发展中起着关键作用。活性氧和活性氮(RNS)引起炎症、组织破坏和唾液腺功能障碍。菊科植物,如洋甘菊、金盏花、凤仙花、蒲公英、牛蒡、千叶阿喀琉叶和金牛花,都具有显著的抗氧化、抗炎和抗菌特性,有助于对抗氧化性氧化和支持口腔内稳态。结论:菊科和紫堇科在治疗os相关口腔疾病方面具有很高的治疗潜力。它们的生物活性化合物有助于恢复氧化还原平衡和保护口腔组织。这些发现支持将植物治疗药物整合到口腔保健中,并呼吁进一步临床验证以植物为基础的疾病预防和管理策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae.

Background/Objectives: Oral health is a complex concept involving physical, psychological, emotional, and social components. A key factor in maintaining oral tissue integrity is redox balance, which is disrupted by oxidative stress (OS) through an imbalance between reactive oxygen species (ROS) and antioxidant defenses. This study examines the contribution of endogenous and exogenous sources to OS and explores the therapeutic potential of medicinal plants from the Asteraceae and Lamiaceae families in restoring redox homeostasis and improving oral health. Methods: A literature review was conducted, analyzing the role of OS in oral diseases and the antioxidant mechanisms of selected Asteraceae species. Special attention was given to their phytochemical contents-polyphenols, flavonoids, and essential oils-and their biological relevance to oral health. Results: OS plays a critical role in the onset and progression of oral conditions such as caries, periodontitis, gingivitis, aphthous ulcers, abscesses, precancerous lesions, and oral cancers. ROS and reactive nitrogen species (RNS) cause inflammation, tissue breakdown, and salivary gland dysfunction. Asteraceae plants like Matricaria chamomilla, Calendula officinalis, Cichorium intybus, Taraxacum officinale, Arctium lappa, Achillea millefolium, and Solidago virgaurea demonstrate notable antioxidant, anti-inflammatory, and antimicrobial properties that help counteract OS and support oral homeostasis. Conclusions: Asteraceae and Lamiaceae species show high therapeutic potential in addressing OS-related oral disorders. Their bioactive compounds aid in restoring redox balance and protecting oral tissues. These findings support the integration of phytotherapeutic agents into oral healthcare and call for further clinical validation of plant-based strategies for disease prevention and management.

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来源期刊
Dentistry Journal
Dentistry Journal Dentistry-Dentistry (all)
CiteScore
3.70
自引率
7.70%
发文量
213
审稿时长
11 weeks
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