eb病毒在原发性积液性淋巴瘤中的关键作用

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2025-05-28 DOI:10.1007/82_2025_310

Beniah Brumbaugh, Bill Sugden

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引用次数: 0

摘要

有些人类癌症是由同时感染两种病毒引起的。原发性积液性淋巴瘤（PEL）是由B细胞与卡波西肉瘤相关疱疹病毒（KSHV）和eb病毒（EBV）共同感染引起的，通常伴有人类免疫缺陷病毒（HIV）的全身感染。KSHV和EBV都有助于一种罕见的B细胞亚群的肿瘤形成，而HIV通过限制宿主对共感染细胞的免疫反应也可以。两种肿瘤病毒介导的淋巴瘤发生的一些机制是清楚的；有些仍有待阐明。

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A Critical Role for Epstein-Barr Virus in Primary Effusion Lymphoma.

Some human cancers are caused by coinfections with two viruses. Here we focus on primary effusion lymphomas (PEL), which arise from coinfection of B cells with Kaposi's Sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) and often are accompanied by systemic infections with human immunodeficiency virus (HIV). Both KSHV and EBV contribute to this oncogenesis of a rare B cell subset and HIV, by limiting the host immune response to coinfected cells, can too. Some of the mechanisms underlying the lymphomagenesis mediated by two tumor viruses are clear; some remain to be elucidated.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.