{"title":"预测坏死性外耳炎的死亡率：Charlson合并症指数。","authors":"Dalton Barham, Stan Mckenzie, Glen Watson","doi":"10.1111/coa.14336","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Necrotising Otitis Externa (NOE) is a severe infection of the ear canal and skull base with a significant morbidity and mortality. There is a limited evidence base to help prognosticate in NOE, focused mainly on disease volume and associated damage. In this retrospective case series, we examined the potential use of the Charlson comorbidity index (CCI) in patients with confirmed NOE to determine its potential use as an additional prognostic indicator.</p><p><strong>Methods: </strong>Retrospective cohort analysis of 87 patients diagnosed with NOE over a 6-year period at a tertiary centre. We calculated the CCI for these patients and collected mortality data at 1 year. A logistic regression was used to analyse the data.</p><p><strong>Results: </strong>The mean CCI was 5.9. A higher score was a reliable indicator of 1-year mortality for patients with NOE with an odds ratio of 1.34 (p = 0.028).</p><p><strong>Conclusion: </strong>The CCI can be considered as a potential adjunct in patients presenting with NOE to guide prognostication and inform decision-making with patients.</p>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predicting Mortality in Necrotising Otitis Externa: The Charlson Comorbidity Index.\",\"authors\":\"Dalton Barham, Stan Mckenzie, Glen Watson\",\"doi\":\"10.1111/coa.14336\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Necrotising Otitis Externa (NOE) is a severe infection of the ear canal and skull base with a significant morbidity and mortality. There is a limited evidence base to help prognosticate in NOE, focused mainly on disease volume and associated damage. In this retrospective case series, we examined the potential use of the Charlson comorbidity index (CCI) in patients with confirmed NOE to determine its potential use as an additional prognostic indicator.</p><p><strong>Methods: </strong>Retrospective cohort analysis of 87 patients diagnosed with NOE over a 6-year period at a tertiary centre. We calculated the CCI for these patients and collected mortality data at 1 year. A logistic regression was used to analyse the data.</p><p><strong>Results: </strong>The mean CCI was 5.9. A higher score was a reliable indicator of 1-year mortality for patients with NOE with an odds ratio of 1.34 (p = 0.028).</p><p><strong>Conclusion: </strong>The CCI can be considered as a potential adjunct in patients presenting with NOE to guide prognostication and inform decision-making with patients.</p>\",\"PeriodicalId\":10431,\"journal\":{\"name\":\"Clinical Otolaryngology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Otolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/coa.14336\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/coa.14336","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Predicting Mortality in Necrotising Otitis Externa: The Charlson Comorbidity Index.
Introduction: Necrotising Otitis Externa (NOE) is a severe infection of the ear canal and skull base with a significant morbidity and mortality. There is a limited evidence base to help prognosticate in NOE, focused mainly on disease volume and associated damage. In this retrospective case series, we examined the potential use of the Charlson comorbidity index (CCI) in patients with confirmed NOE to determine its potential use as an additional prognostic indicator.
Methods: Retrospective cohort analysis of 87 patients diagnosed with NOE over a 6-year period at a tertiary centre. We calculated the CCI for these patients and collected mortality data at 1 year. A logistic regression was used to analyse the data.
Results: The mean CCI was 5.9. A higher score was a reliable indicator of 1-year mortality for patients with NOE with an odds ratio of 1.34 (p = 0.028).
Conclusion: The CCI can be considered as a potential adjunct in patients presenting with NOE to guide prognostication and inform decision-making with patients.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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