脑源性神经营养因子与疾病相关性营养不良患者肌肉减少症相关

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Daniel de Luis, David Primo, Olatz Izaola, Juan José López Gómez
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引用次数: 0

摘要

肌肉减少症是一种以肌肉质量减少为特征的疾病。一些研究已经证明脑源性神经营养因子(BDNF)在慢性肾病患者肌肉减少症中的保护作用。目的:我们旨在探讨循环BDNF在疾病相关性营养不良(DRM)患者肌肉减少症发生中的作用。材料和方法:根据全球营养不良领导倡议(GLIM)标准,共纳入160例诊断为DRM的患者。测量了人体测量数据、超声在股四头直肌(RFQ)水平评估的肌肉质量、生物电阻抗分析(骨骼肌质量(SMM)、阑尾骨骼肌质量(aSMM)和阑尾骨骼肌质量指数(aSMMI))、握力、生化参数、饮食摄入量和BDNF循环水平。结果:55例(34.4%)为肌少症,105例(65.6%)为非肌少症。相位角(-0.6±0.2º;p=0.01),电抗(-5.8±2.1欧姆;p=0.03), SMM(-3.3±0.2 kg;p=0.04), aSMM(-2.1±0.3 kg;p=0.03), aSMMI(-0.8±0.2 kg;P =0.03),优势肌面积(-0.7±0.2 cm²;p=0.04)和优势y轴厚度(-0.4±0.1 cm;P =0.03)。非肌少症患者的肌周强度更高(8.5±1.2 kg;p = 0.01)。非肌少症患者的循环BDNF水平明显高于肌少症患者(94.7±3.9 ng/mL;p = 0.01)。Logistic回归分析显示肌肉减少症的风险降低(OR = 0.16, 95% CI = 0.11-0.43;在调整BMI、性别、能量摄入和年龄后,BDNF水平较高的患者p = 0.03)。结论:我们的研究确定了低血清BDNF水平与疾病相关性营养不良(DRM)患者肌肉减少症之间的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BRAIN-DERIVED NEUROTROPHIC FACTOR IS RELATED WITH SARCOPENIA IN PATIENTS WITH DISEASE RELATED MALNUTRITION.

Introduction: Sarcopenia is a condition characterized by muscle mass loss. Some investigations have demonstrated the role of Brain-derived neurotrophic factor (BDNF) as a protector against the presence of sarcopenia in patients with chronic kidney disease.

Objective: We aimed to explore the role of circu-lating BDNF in the development of sarcopenia among individuals with disease-related malnutrition (DRM).

Material and methods: A total of 160 patients di-agnosed with DRM according to the Global Leadership Initiative on Malnutrition (GLIM) criteria were enrolled. Anthropometric data, muscle mass assessed via ultrasound at the rectus femoris quadriceps (RFQ) level, bioelectrical imped-ance analysis (skeletal muscle mass (SMM), appendicular skeletal muscle mass (aSMM), and appendicular skeletal muscle mass index (aSMMI)), hand-grip strength, biochemical parameters, dietary intake, and circulating levels of BDNF were measured.

Results: A total of 55 patients (34.4%) were classified as sarcopenic, while 105 patients (65.6%) were classified as non-sarcopenic. Phase angle (-0.6±0.2º; p=0.01), reactance (-5.8±2.1 Ohms; p=0.03), SMM (-3.3±0.2 kg; p=0.04), aSMM (-2.1 ±0.3 kg; p=0.03), aSMMI (-0.8±0.2 kg; p=0.03), dominant muscle area (-0.7±0.2 cm²; p=0.04) and dominant Y-axis thickness (-0.4±0.1 cm; p=0.03) were worse in patients with sarcopenia. Mus-cle strength was higher in non-sarcopenic patients (8.5 ± 1.2 kg; p=0.01). Cir-culating BDNF levels were significantly higher in non-sarcopenic patients com-pared to sarcopenic patients (94.7±3.9 ng/mL; p=0.01). Logistic regression analysis indicated a reduced risk of sarcopenia (OR = 0.16, 95% CI = 0.11-0.43; p = 0.03) in patients with higher BDNF levels, after adjusting for BMI, gender, energy intake, and age.

Conclusion: Our study identified an associa-tion between low serum BDNF levels and sarcopenia in patients with disease-related malnutrition (DRM).

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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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