室温下远端非活化C(sp3)-H键的双光氧化还原/铜催化选择性二氟甲基硫基化。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-27 DOI:10.1039/d5ob00257e

Shengwen Li, Guanfeng Ji, Wengui Wang, Shoufeng Wang

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引用次数: 0

摘要

报道了用n -氟磺酰胺光催化/铜双催化远端非活化C(sp3)-H键的二氟甲基硫基化反应。光氧化还原与铜催化相结合，反应条件温和，底物范围广。荧光猝灭实验表明，n -氟磺胺和铜催化剂都能猝灭Ru配合物的激发态。C(sp3)-H键的一级、二级和三级键可以转化，为构建含二氟甲基硫化合物提供了一种有效的方法。

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Dual photoredox/copper-catalyzed selective difluoromethylthiolation of remote unactivated C(sp³)-H bonds at room temperature.

A photocatalysis/copper dual-catalyzed difluoromethylthiolation of remote unactivated C(sp³)-H bonds using N-fluorosulfonamides was reported. The combination of photoredox and copper catalysis led to mild reaction conditions with a broad substrate scope. Luminescence quenching experiments revealed that both N-fluorosulfonamides and the copper catalyst could quench the excited state of the Ru complex. Primary, secondary and tertiary C(sp³)-H bonds could be transformed, offering an efficient way to construct difluoromethylthio-bearing compounds.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.