封面特征：采用“决定性”后期Barton-McCombie脱氧的(+)-和(−)-肉豆蔻油酚的不对称全合成

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-05-27 DOI:10.1002/chem.202583003

Adrien Denizet, Rajesh Nomula, Richard Edwards, Patrick Y. Toullec, Philippe A. Peixoto

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引用次数: 0

摘要

在所谓的Barton-McCombie脱氧反应的第一份报告发表近50年后，利用一种手性氯硫代甲酸型试剂开发出了这种转化的一种分辨率版本。这种方法的实用性被证明了它的后期应用，以获得肉豆蔻碱的两个对映体，一个复杂的四环生物碱。更多信息可以在p.a. Peixoto#和同事的研究文章中找到（DOI: 10.1002/chem.202500267）。

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Cover Feature: Asymmetric Total Synthesis of (+)- and (−)-Myrioneurinol Employing a “Resolutive” Late-Stage Barton-McCombie Deoxygenation

Almost 50 years after the first report of the so-called Barton–McCombie deoxygenation reaction, a resolutive version of this transformation has been developed by using a chiral chlorothionoformate-type reagent. The utility of this method was demonstrated by its late-stage application to access both enantiomers of myrioneurinol, a complex tetracyclic alkaloid. More information can be found in the Research Article by P. A. Peixoto# and co-workers (DOI: 10.1002/chem.202500267).

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.