Research progress on extraction and purification, structural characteristics, pharmacological activities, structure-activity relationships, and applications of Chrysanthemum indicum L. polysaccharides: A review

Chrysanthemum indicum L. (C. indicum) is a broadly dispersed natural medicinal plant belonging to the genus Chrysanthemum within the family Asteraceae. As an herb medicine and a novel food resource, it possesses multifaceted values such as ornamental, edible and even medicinal. The polysaccharides in C. indicum constitute a significant active component, exhibiting gratifying and remarkable pharmacological activities, including antiviral, alleviating liver damage, anti-glycation, antioxidant, and promoting wound healing effects. The article summarizes the research progress of the extraction and purification, structural characteristics, pharmacological activities, structural modifications, structure-activity relationships, and applications of C. indicum polysaccharides for the first time. Moreover, the current situation of related patent research is expounded, and the potential mechanism behind the pharmacological activities of C. indicum polysaccharides is elucidated. Meanwhile, the current limitations in the research on C. indicum polysaccharides have been analyzed, and future research directions have been proposed. Aiming to provide insights and perspectives for the in-depth exploration and study of C. indicum polysaccharides.