凝视行为、面部情绪加工和神经基础:自闭症谱系障碍和品行障碍青少年的比较。

IF 6.5 1区 医学 Q1 PSYCHIATRY
Antonia Tkalcec,Alessandro Baldassarri,Alex Junghans,Vithusan Somasundaram,Willeke M Menks,Lynn V Fehlbaum,Réka Borbàs,Nora Raschle,Gudrun Seeger-Schneider,Bettina Jenny,Susanne Walitza,David M Cole,Philipp Sterzer,Francesco Santini,Evelyn Herbrecht,Ana Cubillo,Christina Stadler
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引用次数: 0

摘要

面部情绪处理缺陷和非典型凝视常被描述为自闭症谱系障碍(ASD)、品行障碍(CD)和高冷酷无情(CU)特征的个体。然而,这些缺陷的潜在神经机制仍不清楚。这项研究的目的是调查眼睛凝视是否可以部分解释患有ASD, CD和典型发育青少年(TD)的大脑激活差异。方法共105例青少年被试(NCD = 39, NASD = 27, NTD = 39;平均年龄= 15.59岁)在完成内隐情绪处理任务期间接受了脑功能成像,包括眼动追踪,而父母/照顾者则完成了问卷调查。使用贝叶斯分析研究了任务中不同面部表情(中性、恐惧、愤怒)的注视行为(注视眼睛和嘴巴区域的次数)的组间差异。使用全因子模型来研究大脑激活的组间差异,包括凝视行为参数和关注潜在面部情绪处理的大脑区域(脑岛、杏仁核和内侧前额叶皮层)。结果ASD患儿与TD组和CD组相比,对口腔的注视增加。与TD相比,具有高CU特征的CD参与者倾向于在所有情绪中对眼睛区域的注视较少。脑成像结果显示,与CD组相比,ASD组在看到愤怒的面孔时右脑岛前部的激活程度更高。在模型中加入凝视行为参数减小了聚类的大小。结论注视行为可以部分解释脑岛激活的差异。这意味着凝视行为在面部情绪处理中起着重要作用,这应该在未来的脑成像研究中得到考虑。此外,我们的研究结果表明,在干预中瞄准凝视行为可能对与情绪面孔处理相关的障碍有潜在的益处。不同诊断中眼睛凝视、CU特征和神经功能之间的关系需要在更大的样本中进一步明确。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder.
BACKGROUND Facial emotion processing deficits and atypical eye gaze are often described in individuals with autism spectrum disorder (ASD) and those with conduct disorder (CD) and high callous unemotional (CU) traits. Yet, the underlying neural mechanisms of these deficits are still unclear. The aim of this study was to investigate if eye gaze can partially account for the differences in brain activation in youth with ASD, with CD, and typically developing youth (TD). METHODS In total, 105 adolescent participants (NCD = 39, NASD = 27, NTD = 39; mean age = 15.59 years) underwent a brain functional imaging session including eye tracking during an implicit emotion processing task while parents/caregivers completed questionnaires. Group differences in gaze behavior (number of fixations to the eye and mouth regions) for different facial expressions (neutral, fearful, angry) presented in the task were investigated using Bayesian analyses. Full-factorial models were used to investigate group differences in brain activation with and without including gaze behavior parameters and focusing on brain regions underlying facial emotion processing (insula, amygdala, and medial prefrontal cortex). RESULTS Youth with ASD showed increased fixations on the mouth compared to TD and CD groups. CD participants with high CU traits tended to show fewer fixations to the eye region compared to TD for all emotions. Brain imaging results show higher right anterior insula activation in the ASD compared with the CD group when angry faces were presented. The inclusion of gaze behavior parameters in the model reduced the size of that cluster. CONCLUSIONS Differences in insula activation may be partially explained by gaze behavior. This implies an important role of gaze behavior in facial emotion processing, which should be considered for future brain imaging studies. In addition, our results suggest that targeting gaze behavior in interventions might be potentially beneficial for disorders showing impairments associated with the processing of emotional faces. The relation between eye gaze, CU traits, and neural function in different diagnoses needs further clarification in larger samples.
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来源期刊
CiteScore
13.80
自引率
5.30%
发文量
169
审稿时长
1 months
期刊介绍: The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.
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