基因组合成揭示了隐藏的增强子保护

IF 29 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-05-27 DOI:10.1038/s41588-025-02194-2

Alex de Mendoza

引用次数: 0

摘要

增强子序列的进化速度很快，这导致了一种普遍的观点，即大多数增强子序列在物种间并不是功能保守的。现在，一项研究通过利用物种间点投影来挑战这一假设，这是一种利用基因组合成来发现隐藏的增强子保护的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Genome synteny reveals hidden enhancer conservation

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Genome synteny reveals hidden enhancer conservation

Enhancer sequences evolve rapidly, which has led to the prevailing view that most are not functionally conserved across species. A study now challenges this assumption by leveraging interspecies point projection — a method that uses genome synteny to uncover hidden enhancer conservation.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution