我们能否通过恢复微生物多样性来改善免疫健康？

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-05-27 DOI:10.1038/s41577-025-01190-1

Aki Sinkkonen, Marja Roslund, Chrysanthi Skevaki, Blandina T. Mmbaga, Kari C. Nadeau, Harald Renz

{"title":"我们能否通过恢复微生物多样性来改善免疫健康？","authors":"Aki Sinkkonen, Marja Roslund, Chrysanthi Skevaki, Blandina T. Mmbaga, Kari C. Nadeau, Harald Renz","doi":"10.1038/s41577-025-01190-1","DOIUrl":null,"url":null,"abstract":"Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial exposures for shaping the immune system. Here we highlight recent clinical trials that have attempted to restore immune regulation by increasing microbial biodiversity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"132 1","pages":""},"PeriodicalIF":67.7000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can we improve immune health by restoring microbial biodiversity?\",\"authors\":\"Aki Sinkkonen, Marja Roslund, Chrysanthi Skevaki, Blandina T. Mmbaga, Kari C. Nadeau, Harald Renz\",\"doi\":\"10.1038/s41577-025-01190-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial exposures for shaping the immune system. Here we highlight recent clinical trials that have attempted to restore immune regulation by increasing microbial biodiversity.\",\"PeriodicalId\":19049,\"journal\":{\"name\":\"Nature Reviews Immunology\",\"volume\":\"132 1\",\"pages\":\"\"},\"PeriodicalIF\":67.7000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41577-025-01190-1\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41577-025-01190-1","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

在生命早期接触不同的微生物可降低炎症状况的风险，包括过敏和自身免疫。新出现的数据表明，微生物多样性与微生物暴露对塑造免疫系统同样重要。在这里，我们重点介绍了最近的临床试验，这些试验试图通过增加微生物生物多样性来恢复免疫调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Can we improve immune health by restoring microbial biodiversity?

查看原文本刊更多论文

Can we improve immune health by restoring microbial biodiversity?

Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial exposures for shaping the immune system. Here we highlight recent clinical trials that have attempted to restore immune regulation by increasing microbial biodiversity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.