利用空间免疫预测肝细胞癌复发

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2025-05-27 DOI:10.1016/j.jhep.2025.04.012

Valerie Chew

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引用次数: 0

摘要

背景和背景肝细胞癌（HCC）是全球癌症相关死亡的第三大原因，预计到2040年，其发病率和死亡率将增加50%以上，2在切除后的最初几年内，复发率约为70%，造成了高昂的医疗负担预测术后复发风险对改善患者预后和优化治疗策略至关重要。传统的临床分期系统，如目的、方法和发现，尽管手术技术有所改进，但肝癌切除术后的复发率仍然很高，而且不充分可预测。Jia及其同事旨在通过综合多步骤方法构建一种预后工具——肿瘤免疫微环境空间（TIMES）评分他们首先对17例HCC患者的发现队列进行了空间转录组学分析，重点关注TME内免疫细胞的空间定位，特别是在肿瘤中心和发现的意义。考虑到空间转录组学的扩展和不断发展及其在组织生物学理解中的应用，这项研究是及时的通过整合空间免疫图谱，本研究代表了我们对HCC复发的理解的重大进展，并为未来的研究奠定了基础，以扩大空间生物标志物在临床实践中的应用。除了具有预后价值外，TIMES评分还提供了对免疫细胞定位和财政支持的重要见解。这项工作得到了新加坡国家医学研究委员会（NMRC）（参考编号：cirg227 -0025， NMRC/OFLCG/003/2018）和新加坡国家研究基金会（参考编号：NRF-CRP26-2021-0005）的支持。利益冲突作者声明没有利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Harnessing spatial immunity to predict recurrence in hepatocellular carcinoma

Section snippets

Background and context

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally, with its incidence and mortality projected to increase by over 50% by 2040.¹^,² A high recurrence rate of approximately 70% typically occurs within the first few years after resection, contributing to a high healthcare burden.³ The prediction of recurrence risk post-resection would be critical to improve patient outcomes and optimize treatment strategies. Traditionally, clinical staging systems such as

Objectives, methods and findings

Despite improvements in surgical techniques, HCC recurrence rates after resection remain high³ and insufficiently predictable. Jia and colleagues aimed to construct a prognostic tool, the Tumor Immune Microenvironment Spatial (TIMES) score, through a comprehensive multi-step approach.⁶ They first performed spatial transcriptomic analysis from a discovery cohort of 17 patients with HCC, focusing on the spatial localization of immune cells within the TME, specifically in the tumor center and at

Significance of findings

This study is timely, given the expansion and continual advancement of spatial transcriptomics and its application in understanding tissue biology.⁷ By integrating spatial immune profiling, this study represents a significant advance in our understanding of HCC recurrence and lays the groundwork for future studies to expand the use of spatial biomarkers in clinical practice. In addition to its prognostic value, the TIMES score provides important insights into immune cell localization and

Financial support

This work was supported by the National Medical Research Council (NMRC), Singapore (reference number: CIRG22jul-0025, NMRC/OFLCG/003/2018) and National Research Foundation, Singapore (ref number: NRF-CRP26-2021-0005).

Conflict of interest

The author declared no conflict of interest.

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来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.