肢端肥大症患者的中耳转移功能。

Eray Bayindir, Emel Aslantas, Bulent Can, Berina Slipcevic, Serdal Celik, Basak Mutlu, Mahmut Tayyar Kalcioglu
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引用次数: 0

摘要

背景:肢端肥大症是一种罕见的疾病,其生长激素是由脑垂体分泌不受控制。考虑到肢端肥大症对中耳(ME)传递功能和听力的病理影响的风险,本研究旨在应用宽频带鼓膜测量法(WBT)研究经蝶窦手术的肢端肥大症患者的ME传递功能。方法:对所有受试者进行纯音听力测定(PTA)、226 Hz探测音声学阻抗测定和WBT测定。本研究包括28例肢端肥大症患者和29例健康受试者。结果:肢端肥大症组(男11例,女17例)的平均年龄为49.25±9.57岁,健康对照组(男13例,女16例)的平均年龄为45±10.02岁。肢端肥大症组与健康组PTA均值均在正常范围内,但肢端肥大症组PTA均值(20.73±10.95)明显低于健康组(12.02±6.67,P = 0.000)。肢端肥大症组和健康组无加压和加压WBT吸光度差异无统计学意义。肢端肥大症组在1000 Hz时的等效耳道体积(P= 0.041)和平均WBT测量的等效耳道体积(P= 0.023)均大于健康对照组。结论:调查显示,肢端肥大症患者的等效耳道容积有统计学意义。然而,这并不影响ME传递函数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Middle Ear Transfer Function in Acromegaly Patients.

BACKGROUND: Acromegaly is a rare disorder in which growth hormone is secreted uncontrollably by the pituitary gland. Considering the risk of pathological effects of acromegaly on middle ear (ME) transfer function and hearing, we aimed to investigate the ME transfer functions of acromegaly patients who underwent transsphenoidal surgery using wide-band tympanometry (WBT) in this study. METHODS: Pure tone audiometry (PTA), 226 Hz probe-tone acoustic immitancemetry, and WBT were performed on all participants. Twenty-eight patients with acromegaly and 29 healthy subjects were included in the current study. RESULTS: The mean age of the acromegaly group (11 males, 17 females) was 49.25 ± 9.57 years, and that of the healthy controls (13 males, 16 females) was 45 ± 10.02 years. The PTA means of the acromegaly and healthy groups were between normal limits, but the mean of the acromeg- aly group (20.73 ± 10.95) was significantly worse than that of the healthy group (12.02 ± 6.67, P = .000). The WBT non-pressurized and pressurized absorbance values of the acromegaly and healthy groups did not show statistically significant differences. The equivalent ear canal volumes at 1000 Hz (P =.041) and the equivalent ear canal volume measured by averaging the WBT (P=.023) of the acromegaly group were larger than those of the healthy controls. CONCLUSION: The investigation revealed that the equivalent ear canal volumes were statistically significantly higher in patients with acromeg- aly. However, this did not impact the ME transfer function.

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