手术切除联合辅助放疗治疗瘢痕疙瘩的疗效观察。

Annals of burns and fire disasters Pub Date : 2025-03-31 eCollection Date: 2025-03-01
D Barreiro, M Mendes, P Machado, S Gomes, P Soares, R Horta
{"title":"手术切除联合辅助放疗治疗瘢痕疙瘩的疗效观察。","authors":"D Barreiro, M Mendes, P Machado, S Gomes, P Soares, R Horta","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Keloid is a benign dermal condition that occurs due to excessive activation of fibroblasts, which leads to an abnormal accumulation of collagen. There are several treatment options, but none have been satisfactory or optimal. Often, combined treatments are used due to its high recurrence rate after surgical excision alone. The aim of this study is to evaluate the efficacy of adjuvant radiotherapy after surgical excision. A retrospective study was performed including patients with keloid scars who underwent surgical excision and adjuvant radiotherapy between May 2016 and March 2020. The data was collected from the radiotherapy and plastic surgery medical charts. There were 13 patients identified. The patient and observer scar assessment scale (POSAS) was performed in all 13 patients. The treatment used was surgical excision of the scar associated with 9 Gy radiotherapy dose within the first 24 hours after the surgery, plus another session after 7 days. 13 patients and 16 keloid scars were evaluated during a mean follow-up period of 13,5 months 95%CI (5,84; 21,16). There was no major adverse event from the treatment used. According to POSAS, the overall satisfaction rate was significantly good (mean of 2,29 on a scale from 1 to 10). Only one recurrence was observed (6.25%). Keloids are difficult to treat due to their high recurrence rate. There is no consent about the best treatment. This study showed that surgical excision combined with adjuvant radiotherapy is an excellent option, even for refractory keloids. The aesthetical result was satisfactory and the recurrence rate was low.</p>","PeriodicalId":93873,"journal":{"name":"Annals of burns and fire disasters","volume":"38 1","pages":"59-65"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097506/pdf/","citationCount":"0","resultStr":"{\"title\":\"The efficacy of combined adjuvant radiotherapy with surgical excision in the treatment of keloids.\",\"authors\":\"D Barreiro, M Mendes, P Machado, S Gomes, P Soares, R Horta\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Keloid is a benign dermal condition that occurs due to excessive activation of fibroblasts, which leads to an abnormal accumulation of collagen. There are several treatment options, but none have been satisfactory or optimal. Often, combined treatments are used due to its high recurrence rate after surgical excision alone. The aim of this study is to evaluate the efficacy of adjuvant radiotherapy after surgical excision. A retrospective study was performed including patients with keloid scars who underwent surgical excision and adjuvant radiotherapy between May 2016 and March 2020. The data was collected from the radiotherapy and plastic surgery medical charts. There were 13 patients identified. The patient and observer scar assessment scale (POSAS) was performed in all 13 patients. The treatment used was surgical excision of the scar associated with 9 Gy radiotherapy dose within the first 24 hours after the surgery, plus another session after 7 days. 13 patients and 16 keloid scars were evaluated during a mean follow-up period of 13,5 months 95%CI (5,84; 21,16). There was no major adverse event from the treatment used. According to POSAS, the overall satisfaction rate was significantly good (mean of 2,29 on a scale from 1 to 10). Only one recurrence was observed (6.25%). Keloids are difficult to treat due to their high recurrence rate. There is no consent about the best treatment. This study showed that surgical excision combined with adjuvant radiotherapy is an excellent option, even for refractory keloids. The aesthetical result was satisfactory and the recurrence rate was low.</p>\",\"PeriodicalId\":93873,\"journal\":{\"name\":\"Annals of burns and fire disasters\",\"volume\":\"38 1\",\"pages\":\"59-65\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097506/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of burns and fire disasters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of burns and fire disasters","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

瘢痕疙瘩是一种良性皮肤状况,发生由于过度激活的成纤维细胞,导致胶原蛋白的异常积累。有几种治疗方案,但没有一种是令人满意的或最佳的。由于单纯手术切除后复发率高,通常采用联合治疗。本研究的目的是评估手术切除后辅助放疗的疗效。回顾性研究包括2016年5月至2020年3月期间接受手术切除和辅助放疗的瘢痕疙瘩疤痕患者。数据来自放射治疗和整形外科病历。共发现13例患者。13例患者均行患者及观察者疤痕评定量表(POSAS)。使用的治疗方法是手术切除疤痕,术后24小时内放疗剂量为9gy, 7天后再进行一次放疗。13例患者和16个瘢痕疙瘩在平均随访期间评估,随访时间为13,5个月95%CI (5,84;21日,16)。所使用的治疗没有发生重大不良事件。根据POSAS,整体满意度非常好(在1到10的范围内,平均为2,29)。仅1例复发(6.25%)。瘢痕疙瘩因其高复发率而难以治疗。对于最好的治疗方法没有一致的意见。这项研究表明,手术切除结合辅助放疗是一个很好的选择,即使是难治性瘢痕疙瘩。术后美观效果满意,复发率低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of combined adjuvant radiotherapy with surgical excision in the treatment of keloids.

Keloid is a benign dermal condition that occurs due to excessive activation of fibroblasts, which leads to an abnormal accumulation of collagen. There are several treatment options, but none have been satisfactory or optimal. Often, combined treatments are used due to its high recurrence rate after surgical excision alone. The aim of this study is to evaluate the efficacy of adjuvant radiotherapy after surgical excision. A retrospective study was performed including patients with keloid scars who underwent surgical excision and adjuvant radiotherapy between May 2016 and March 2020. The data was collected from the radiotherapy and plastic surgery medical charts. There were 13 patients identified. The patient and observer scar assessment scale (POSAS) was performed in all 13 patients. The treatment used was surgical excision of the scar associated with 9 Gy radiotherapy dose within the first 24 hours after the surgery, plus another session after 7 days. 13 patients and 16 keloid scars were evaluated during a mean follow-up period of 13,5 months 95%CI (5,84; 21,16). There was no major adverse event from the treatment used. According to POSAS, the overall satisfaction rate was significantly good (mean of 2,29 on a scale from 1 to 10). Only one recurrence was observed (6.25%). Keloids are difficult to treat due to their high recurrence rate. There is no consent about the best treatment. This study showed that surgical excision combined with adjuvant radiotherapy is an excellent option, even for refractory keloids. The aesthetical result was satisfactory and the recurrence rate was low.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信