Dynein: A Multifaceted Therapeutic Target and Its Dysregulation in Aberrant Cell Proliferation.

This review examines the diverse functions of dyneins, a family of motor proteins involved in intracellular transport processes, the maintenance of cell polarity, and critical signaling pathways essential for cell cycle progression. Dyneins' significant impact on critical cellular functions is mediated through their interactions with an array of organelles, including centrosomes, chromosomes, and endosomes. Dyneins also influence autophagy and immune evasion within the complex environment of cancer. This review underscores the significance of dyneins as an avenue of exploration for comprehending the intricate mechanisms that underpin cancer.