以微生物群为基础的膳食补充剂有助于更好的发育和健康的大脑。

International review of neurobiology Pub Date : 2025-01-01 Epub Date: 2025-04-16 DOI:10.1016/bs.irn.2025.03.009
Riddhi Upadhyay, Sugumar Mani, Murugan Sevanan
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引用次数: 0

摘要

以微生物为基础的膳食补充剂因其在促进大脑发育和认知健康方面的作用而受到关注。肠道微生物组通过肠-脑轴影响神经功能,影响神经递质产生、免疫调节和代谢途径。生态失调与阿尔茨海默氏症、帕金森症和自闭症谱系障碍等神经系统疾病有关。本章探讨了针对微生物组的饮食干预,强调益生菌、益生元和后益生菌。此外,人工智能和机器学习通过实现针对个人肠道特征的个性化补充策略,正在改变微生物组研究。还讨论了包括数据隐私和算法偏见在内的道德挑战。大数据分析和预测建模的进步为精准干预铺平了道路,以优化大脑健康。虽然基于微生物组的疗法具有很大的前景,但需要进一步的临床验证和监管框架来确保其有效性和可及性。本章强调了微生物组靶向策略在神经保护和认知健康方面的未来潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiome-based dietary supplements for better development and healthy brain.

Microbiome-based dietary supplements have gained attention for their role in enhancing brain development and cognitive health. The gut microbiome influences neurological functions through the gut-brain axis, impacting neurotransmitter production, immune regulation, and metabolic pathways. Dysbiosis is linked to neurological disorders such as Alzheimer's, Parkinson's, and autism spectrum disorders. This chapter explores dietary interventions targeting the microbiome, emphasising probiotics, prebiotics, and postbiotics. Additionally, AI and machine learning are transforming microbiome research by enabling personalised supplementation strategies tailored to individual gut profiles. Ethical challenges, including data privacy and algorithmic bias, are also discussed. Advances in big data analytics and predictive modelling are paving the way for precision-targeted interventions to optimise brain health. While microbiome-based therapies hold great promise, further clinical validation and regulatory frameworks are needed to ensure their efficacy and accessibility. This chapter highlights the future potential of microbiome-targeted strategies in neuroprotection and cognitive well-being.

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