{"title":"有和没有早期龋齿的学龄前儿童唾液因素与遗传味觉的相关性评估：一项体内研究。","authors":"Anika Kulshrestha, Preetam Shah, Shweta Chaudhary, Laxmi Lakade, Shweta S Jajoo, Krishna Patil","doi":"10.5005/jp-journals-10005-3072","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Early childhood caries (ECC) has a prevalence of 46.9% in India and a complex multifactorial etiology primarily governed by individual food preferences, oral hygiene practices, and salivary constituents. Food preferences are genetically predetermined by the <i>TAS2R38</i> gene, mediating insensitivity to bitter taste, like that of phenylthiouracil (PTC). Based on this, people can be classified as tasters and nontasters, respectively, aiding in determining their caries susceptibility. Oral hygiene practices and saliva also play a major role in the inherent protective mechanisms that can be quantified by measuring the salivary flow rate, buffering capacity, and pH.</p><p><strong>Aim: </strong>The aim of this study was to find a correlation of various salivary factors with PTC taste sensitivity and its comparison in children with and without ECC.</p><p><strong>Materials and methods: </strong>The study comprised 86 participants-43 with and 43 without ECC. The PTC strip test was done to determine genetic taste perception, and facial expressions of the child were recorded. Salivary collection was done, followed by the estimation of buffering capacity, pH, and flow rate. Decayed, missing, and filled teeth (dmft) was then recorded.</p><p><strong>Results: </strong>A strong positive correlation was seen between nontaster participants and ECC. Salivary flow rate and pH were slightly lower in children with ECC. Nontaster caries-free participants also reported a twice-daily brushing habit with fluoridated toothpaste.</p><p><strong>Conclusion: </strong>The present study highlights a strong positive relationship between the occurrence of dental caries in individuals and their genetic taste perception, suggesting that nontasters, who tend to prefer sweeter and more intense flavors, are more prone to dental caries.</p><p><strong>How to cite this article: </strong>Kulshrestha A, Shah P, Chaudhary S, <i>et al</i>. Assessment of Correlation of Salivary Factors with Genetic Taste Perception in Preschool Children with and without Early Childhood Caries: An <i>In Vivo</i> Study. Int J Clin Pediatr Dent 2025;18(3):293-298.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 3","pages":"293-298"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096884/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of Correlation of Salivary Factors with Genetic Taste Perception in Preschool Children with and without Early Childhood Caries: An <i>In Vivo</i> Study.\",\"authors\":\"Anika Kulshrestha, Preetam Shah, Shweta Chaudhary, Laxmi Lakade, Shweta S Jajoo, Krishna Patil\",\"doi\":\"10.5005/jp-journals-10005-3072\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Early childhood caries (ECC) has a prevalence of 46.9% in India and a complex multifactorial etiology primarily governed by individual food preferences, oral hygiene practices, and salivary constituents. Food preferences are genetically predetermined by the <i>TAS2R38</i> gene, mediating insensitivity to bitter taste, like that of phenylthiouracil (PTC). Based on this, people can be classified as tasters and nontasters, respectively, aiding in determining their caries susceptibility. Oral hygiene practices and saliva also play a major role in the inherent protective mechanisms that can be quantified by measuring the salivary flow rate, buffering capacity, and pH.</p><p><strong>Aim: </strong>The aim of this study was to find a correlation of various salivary factors with PTC taste sensitivity and its comparison in children with and without ECC.</p><p><strong>Materials and methods: </strong>The study comprised 86 participants-43 with and 43 without ECC. The PTC strip test was done to determine genetic taste perception, and facial expressions of the child were recorded. Salivary collection was done, followed by the estimation of buffering capacity, pH, and flow rate. Decayed, missing, and filled teeth (dmft) was then recorded.</p><p><strong>Results: </strong>A strong positive correlation was seen between nontaster participants and ECC. Salivary flow rate and pH were slightly lower in children with ECC. Nontaster caries-free participants also reported a twice-daily brushing habit with fluoridated toothpaste.</p><p><strong>Conclusion: </strong>The present study highlights a strong positive relationship between the occurrence of dental caries in individuals and their genetic taste perception, suggesting that nontasters, who tend to prefer sweeter and more intense flavors, are more prone to dental caries.</p><p><strong>How to cite this article: </strong>Kulshrestha A, Shah P, Chaudhary S, <i>et al</i>. Assessment of Correlation of Salivary Factors with Genetic Taste Perception in Preschool Children with and without Early Childhood Caries: An <i>In Vivo</i> Study. 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引用次数: 0
摘要
背景：儿童早期龋齿（ECC）在印度的患病率为46.9%，其病因复杂，主要受个人食物偏好、口腔卫生习惯和唾液成分的影响。食物偏好是由TAS2R38基因决定的，它介导了对苦味的不敏感，比如苯硫脲嘧啶（PTC）。在此基础上，人们可以分为味觉者和非味觉者，这有助于确定他们对龋齿的易感性。口腔卫生习惯和唾液在固有的保护机制中也起着重要作用，可以通过测量唾液流量、缓冲能力和ph来量化。目的：本研究的目的是寻找各种唾液因素与PTC味觉敏感性的相关性，并比较有无ECC儿童的PTC味觉敏感性。材料和方法：该研究包括86名参与者，其中43名患有ECC， 43名没有ECC。通过PTC条带测试来确定遗传味觉，并记录儿童的面部表情。收集唾液，然后估计缓冲能力，pH值和流速。然后记录蛀牙、缺牙和补牙（dmft）。结果：味觉障碍者与ECC之间存在强正相关。ECC患儿唾液流速和pH值稍低。没有蛀牙的参与者也报告了每天用含氟牙膏刷牙两次的习惯。结论：目前的研究强调了个体蛀牙的发生与他们的遗传味觉之间存在强烈的正相关关系，这表明那些倾向于更甜、更强烈的口味的味觉者更容易患蛀牙。如何引用本文：Kulshrestha A， Shah P， Chaudhary S等。有和没有早期龋齿的学龄前儿童唾液因素与遗传味觉的相关性评估：一项体内研究。中华临床儿科杂志，2015;18(3):293-298。
Assessment of Correlation of Salivary Factors with Genetic Taste Perception in Preschool Children with and without Early Childhood Caries: An In Vivo Study.
Background: Early childhood caries (ECC) has a prevalence of 46.9% in India and a complex multifactorial etiology primarily governed by individual food preferences, oral hygiene practices, and salivary constituents. Food preferences are genetically predetermined by the TAS2R38 gene, mediating insensitivity to bitter taste, like that of phenylthiouracil (PTC). Based on this, people can be classified as tasters and nontasters, respectively, aiding in determining their caries susceptibility. Oral hygiene practices and saliva also play a major role in the inherent protective mechanisms that can be quantified by measuring the salivary flow rate, buffering capacity, and pH.
Aim: The aim of this study was to find a correlation of various salivary factors with PTC taste sensitivity and its comparison in children with and without ECC.
Materials and methods: The study comprised 86 participants-43 with and 43 without ECC. The PTC strip test was done to determine genetic taste perception, and facial expressions of the child were recorded. Salivary collection was done, followed by the estimation of buffering capacity, pH, and flow rate. Decayed, missing, and filled teeth (dmft) was then recorded.
Results: A strong positive correlation was seen between nontaster participants and ECC. Salivary flow rate and pH were slightly lower in children with ECC. Nontaster caries-free participants also reported a twice-daily brushing habit with fluoridated toothpaste.
Conclusion: The present study highlights a strong positive relationship between the occurrence of dental caries in individuals and their genetic taste perception, suggesting that nontasters, who tend to prefer sweeter and more intense flavors, are more prone to dental caries.
How to cite this article: Kulshrestha A, Shah P, Chaudhary S, et al. Assessment of Correlation of Salivary Factors with Genetic Taste Perception in Preschool Children with and without Early Childhood Caries: An In Vivo Study. Int J Clin Pediatr Dent 2025;18(3):293-298.
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