{"title":"非洲人类免疫缺陷病毒感染者的感觉神经病变及其相关因素：一项系统回顾和荟萃分析","authors":"Worku Chekol Tassew, Ashebir Mamay Gebiru, Mihret Getnet, Berihun Agegn Mengistie, Desalegn Anmut Bitew, Amare Belete Getahun, Desale Bihonegn Asmamaw, Mikias Mered Tilahun, Mihret Melese, Nebebe Demis Baykemagn, Yimer Mamaye, Yosef Belay Bizuneh, Habtu Kifle Negash","doi":"10.1186/s12985-025-02789-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Despite high prevalence of sensory neuropathy among individuals living with HIV, there is no comprehensive information regarding variables that determine sensory neuropathy onset among the patients who attended health care facilities. In conditions where there is a high number of patients with sensory neuropathy, clinicians confront challenges in managing the problem, and increase the burden of health care expenditures. This study aimed to determine the prevalence of peripheral neuropathy and associated factors among people living with HIV in Africa.</p><p><strong>Methods: </strong>To ensure the transparency, accuracy, and thoroughness of this systematic review and meta-analysis, we adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic electronic searches were conducted across several databases, including African Journal Online, Google Scholar, PubMed, Scopus, and the Wiley Online Library. Articles found during the searching were imported into EndNote software version X7, where duplicates were removed. The extracted data were then imported to Microsoft Excel and analyzed using STATA version 11 for analysis. The Q statistic and I<sup>2</sup> test were employed to evaluate heterogeneity between studies.</p><p><strong>Results: </strong>The initial search identified 1,821 articles, which were organized using citation management software. The current meta-analysis found that 36.46% (95% CI: 26.48-46.44, I<sup>2</sup> = 87.1%) patients living with HIV/AIDS experience peripheral sensory neuropathy. Factors associated with peripheral neuropathy included being older than 40 years (OR = 2.40; 95% CI: 01.24, 4.64), having viral load greater than 1,000 copies (OR = 2.46; 95% CI: 1.03, 5.88) and having a CD4 count below 200 cells (OR = 4.30; 95% CI: 1.24, 14.98).</p><p><strong>Conclusion: </strong>This study found that peripheral sensory neuropathy is highly prevalent among HIV-infected individuals in Africa. Advanced age, elevated viral load, and low CD4 count were identified as independent predictors of HIV-related peripheral neuropathy. It is recommended that simple, established neurological screening methods be regularly used to identify early signs of HIV-SN or individuals at risk, across all patients.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"161"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102978/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sensory neuropathy and associated factors among patients living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis.\",\"authors\":\"Worku Chekol Tassew, Ashebir Mamay Gebiru, Mihret Getnet, Berihun Agegn Mengistie, Desalegn Anmut Bitew, Amare Belete Getahun, Desale Bihonegn Asmamaw, Mikias Mered Tilahun, Mihret Melese, Nebebe Demis Baykemagn, Yimer Mamaye, Yosef Belay Bizuneh, Habtu Kifle Negash\",\"doi\":\"10.1186/s12985-025-02789-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Despite high prevalence of sensory neuropathy among individuals living with HIV, there is no comprehensive information regarding variables that determine sensory neuropathy onset among the patients who attended health care facilities. In conditions where there is a high number of patients with sensory neuropathy, clinicians confront challenges in managing the problem, and increase the burden of health care expenditures. This study aimed to determine the prevalence of peripheral neuropathy and associated factors among people living with HIV in Africa.</p><p><strong>Methods: </strong>To ensure the transparency, accuracy, and thoroughness of this systematic review and meta-analysis, we adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic electronic searches were conducted across several databases, including African Journal Online, Google Scholar, PubMed, Scopus, and the Wiley Online Library. Articles found during the searching were imported into EndNote software version X7, where duplicates were removed. The extracted data were then imported to Microsoft Excel and analyzed using STATA version 11 for analysis. The Q statistic and I<sup>2</sup> test were employed to evaluate heterogeneity between studies.</p><p><strong>Results: </strong>The initial search identified 1,821 articles, which were organized using citation management software. The current meta-analysis found that 36.46% (95% CI: 26.48-46.44, I<sup>2</sup> = 87.1%) patients living with HIV/AIDS experience peripheral sensory neuropathy. Factors associated with peripheral neuropathy included being older than 40 years (OR = 2.40; 95% CI: 01.24, 4.64), having viral load greater than 1,000 copies (OR = 2.46; 95% CI: 1.03, 5.88) and having a CD4 count below 200 cells (OR = 4.30; 95% CI: 1.24, 14.98).</p><p><strong>Conclusion: </strong>This study found that peripheral sensory neuropathy is highly prevalent among HIV-infected individuals in Africa. Advanced age, elevated viral load, and low CD4 count were identified as independent predictors of HIV-related peripheral neuropathy. It is recommended that simple, established neurological screening methods be regularly used to identify early signs of HIV-SN or individuals at risk, across all patients.</p>\",\"PeriodicalId\":23616,\"journal\":{\"name\":\"Virology Journal\",\"volume\":\"22 1\",\"pages\":\"161\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102978/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virology Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12985-025-02789-5\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02789-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
Sensory neuropathy and associated factors among patients living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis.
Introduction: Despite high prevalence of sensory neuropathy among individuals living with HIV, there is no comprehensive information regarding variables that determine sensory neuropathy onset among the patients who attended health care facilities. In conditions where there is a high number of patients with sensory neuropathy, clinicians confront challenges in managing the problem, and increase the burden of health care expenditures. This study aimed to determine the prevalence of peripheral neuropathy and associated factors among people living with HIV in Africa.
Methods: To ensure the transparency, accuracy, and thoroughness of this systematic review and meta-analysis, we adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic electronic searches were conducted across several databases, including African Journal Online, Google Scholar, PubMed, Scopus, and the Wiley Online Library. Articles found during the searching were imported into EndNote software version X7, where duplicates were removed. The extracted data were then imported to Microsoft Excel and analyzed using STATA version 11 for analysis. The Q statistic and I2 test were employed to evaluate heterogeneity between studies.
Results: The initial search identified 1,821 articles, which were organized using citation management software. The current meta-analysis found that 36.46% (95% CI: 26.48-46.44, I2 = 87.1%) patients living with HIV/AIDS experience peripheral sensory neuropathy. Factors associated with peripheral neuropathy included being older than 40 years (OR = 2.40; 95% CI: 01.24, 4.64), having viral load greater than 1,000 copies (OR = 2.46; 95% CI: 1.03, 5.88) and having a CD4 count below 200 cells (OR = 4.30; 95% CI: 1.24, 14.98).
Conclusion: This study found that peripheral sensory neuropathy is highly prevalent among HIV-infected individuals in Africa. Advanced age, elevated viral load, and low CD4 count were identified as independent predictors of HIV-related peripheral neuropathy. It is recommended that simple, established neurological screening methods be regularly used to identify early signs of HIV-SN or individuals at risk, across all patients.
期刊介绍：
Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies.
The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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