COVID-19眼微血管变化:缺氧、d -二聚体、IL-6和全身治疗的作用

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Magdalena Kal, Michał Brzdęk, Izabella Karska-Basta, Piotr Rzymski, Antonio Pinna, Mateusz Winiarczyk, Jerzy Mackiewicz, Dominik Odrobina, Dorota Zarębska-Michaluk
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引用次数: 0

摘要

背景:严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)与内皮功能障碍有关,内皮功能障碍也可能损害眼组织内的微循环。这项前瞻性研究评估了2019冠状病毒病(COVID-19)相关肺炎恢复期患者桡动脉乳头周围毛细血管密度(RPC)与全身治疗、年龄、缺氧、d -二聚体和白细胞介素-6 (IL-6)水平之间的关系。方法:63例因COVID-19双侧肺炎入院的患者在出院2个月后进行眼科检查。使用光学相干断层扫描血管造影测量RPC VD。评估与年龄、动脉高血压、全身治疗(地塞米松、瑞德西韦和氧治疗)、血氧饱和度、d -二聚体和IL-6水平的关系。对照组包括43名没有COVID-19病史的对照组参与者,他们参加了常规眼科检查。结果:未见眼部异常。RPC VD与高血压或全身性地塞米松和瑞德西韦治疗无显著差异。然而,接受氧疗的患者有较高的RPC VD。下位RPC VD与年龄呈临界负相关。RPC VD与血氧饱和度无相关性。鼻腔RPC和平均RPC与d -二聚体水平呈显著负相关,下RPC VD与IL-6水平呈显著负相关。与对照组相比,COVID-19组RPC参数无显著差异。结论:高血压或全身治疗对RCP VD无显著影响。然而,特定RPC区域的VD与d -二聚体和IL-6水平呈负相关,这突出表明需要监测乳头周围微血管,以了解COVID-19对眼部的潜在长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ocular microvascular changes in COVID-19: role of hypoxia, D-dimer, IL-6 and systemic treatment.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with endothelial dysfunction, which may also compromise the microcirculation within ocular tissues. This prospective study evaluated associations between radial peripapillary capillary (RPC) vessel density (VD) and systemic treatment, age, hypoxia, D-dimer, and interleukin-6 (IL-6) levels in patients recovering from coronavirus disease 2019 (COVID-19) related pneumonia.

Methods: Sixty-three individuals who were admitted to the hospital due to COVID-19 bilateral pneumonia underwent ophthalmic examination two months post-discharge. RPC VD was measured using optical coherence tomography angiography. Associations with age, arterial hypertension, and systemic treatment (dexamethasone, remdesivir, and oxygen therapy), oxygen saturation, D-dimer, and IL-6 levels were evaluated. The control group comprised 43 control participants with no history of COVID-19 who attended routine ophthalmic examinations.

Results: No ophthalmic abnormalities were detected. RPC VD did not differ significantly with hypertension or systemic treatment with dexamethasone and remdesivir. However, patients receiving oxygen therapy had higher RPC VD. A borderline inverse correlation was observed between inferior RPC VD and age. There were no correlations between RPC VD and oxygen saturation. Significant inverse correlations were found between nasal RPC and mean RPC with D-dimer levels and between inferior RPC VD and IL-6 levels. No significant differences in RPC parameters were observed when comparing the COVID-19 group with controls.

Conclusions: Hypertension or systemic treatment had no significant effect on RCP VD. However, VD in specific RPC areas correlated inversely with D-dimer and IL-6 levels, highlighting the need for monitoring peripapillary microvasculature for potential long-term ocular effects of COVID-19.

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来源期刊
Pharmacological Reports
Pharmacological Reports 医学-药学
CiteScore
8.40
自引率
0.00%
发文量
91
审稿时长
6 months
期刊介绍: Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.
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