AEWS1031登记的局部尤文氏肉瘤患者的术前放疗：一份来自儿童肿瘤组的报告

IF 2.4 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-05-25 DOI:10.1002/pbc.31820

Daniel J Indelicato, Alexandra K Callan, Safia K Ahmed, Mark Krailo, Natalie DelRocco, Allen B Buxton, Odion T Binitie, Alexander B Christ, Sandy Kessell, Paul J Chuba, Helen R Nadel, Bruce R Pawel, Richard Gorlick, Damon R Reed, Steven G DuBois, Katherine A Janeway, Patrick Leavey, Leo Mascarenhas, Nadia N Laack

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引用次数: 0

摘要

可切除的尤因肉瘤（ES）患者在特定部位，如骨盆或胸壁，手术后显微镜边缘阳性的风险更高。AEWS1031是第一个允许标准化术前放疗的北美/澳大拉西亚ES合作组试验，旨在最大限度地减少联合模式局部肿瘤控制的发病率，并提高手术边缘清晰的可能性。在本研究中，我们发现使用低剂量的术前放疗到较小的靶体积导致高R0切除术率。强劲的病理反应率加强了现有的证据，说明尤因肉瘤的放射敏感性。

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Preoperative Radiotherapy in Patients With Localized Ewing Sarcoma Enrolled on AEWS1031: A Report From the Children's Oncology Group.

Patients with resectable Ewing sarcoma (ES) in select sites, such as the pelvis or chest wall, have a higher risk of positive microscopic margins following surgery. AEWS1031 was the first North American/Australasia ES cooperative group trial allowing standardized preoperative radiotherapy, intended to minimize the morbidity of combined modality local tumor control as well as improve the likelihood of clear surgical margins. In this study, we found that the use of low-dose preoperative radiation to a smaller target volume resulted in a high rate of R0 resection. The robust pathologic response rate strengthens existing evidence illustrating the radiosensitivity of Ewing sarcoma.

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.