冠状动脉旁路移植术后红细胞分布宽度-血小板比与死亡率的关系。

IF 2.3 3区生物学 Q2 MULTIDISCIPLINARY SCIENCES

PeerJ Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.7717/peerj.19472

Bufan Zhang, Yize Liu, Jiyang Zuo, Tianxu Song, Naishi Wu

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引用次数: 0

摘要

背景：本研究旨在探讨冠状动脉旁路移植术（CABG）后患者红细胞分布宽度-血小板比（RPR）与死亡率的关系。方法：回顾性收集2021年1月1日至2022年7月31日行冠脉搭桥的患者资料。采用局部加权散点图平滑（Lowess）方法显示RPR与住院死亡率之间的粗略关联。用受试者工作特征曲线下面积（AUC）来评价鉴别效果。采用约登指数法计算RPR的临界值（0.107）。主要终点是住院死亡率。结果：共纳入1258例患者。Lowess曲线显示RPR与住院死亡率呈近似正线性关系。在多变量logistic回归模型中，RPR是CABG术后住院死亡率的独立危险因素（OR为1.493,95% CI[1.119-1.992]，每标准差（SD）增加，p = 0.006）。RPR （AUC 0.716, 95% CI[0.617-0.814]）比RDW （AUC 0.578, 95% CI [0.477-0.680], p = 0.002）具有更大的区别。计算RPR的临界值（0.107）进行进一步分析，并将各组进一步分为高RPR组（≥0.107）和低RPR组（< 0.107）。在多变量logistic回归模型中，高RPR（≥0.107）与院内死亡风险升高相关（OR 6.097, 95% CI [2.308-16.104], p p）。结论：术前高RPR可作为院内死亡率和1年死亡率的独立风险预测因子，可用于评估患者预后，进一步指导CABG术后患者的治疗。

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Association of red blood cell distribution width-platelet ratio with mortality after coronary artery bypass grafting.

Background: This study aims to explore the association between red blood cell distribution width-platelet ratio (RPR) and mortality in patients after coronary artery bypass grafting (CABG).

Methods: Data on patients who underwent CABG from January 1, 2021, to July 31, 2022, were retrospectively collected. The locally weighted scatter plot smoothing (Lowess) method was utilized to display the crude association between RPR and in-hospital mortality. The areas under the receiver operating characteristic curves (AUC) were used to assess the discrimination. The cut-off value (0.107) of RPR was calculated using the Youden index method. The primary outcome was in-hospital mortality.

Results: In total, 1,258 patients were included. The Lowess curve showed an approximate positive linear relationship between RPR and in-hospital mortality. In the multivariable logistic regression model, RPR was an independent risk factor (OR 1.493, 95% CI [1.119-1.992] per standard deviation (SD) increase, p = 0.006) for in-hospital mortality after CABG. RPR (AUC 0.716, 95% CI [0.617-0.814]) demonstrated greater discrimination than RDW (AUC 0.578, 95% CI [0.477-0.680], p = 0.002). The cut-off value (0.107) of RPR was calculated for further analysis, and groups were further divided into the high RPR group (≥ 0.107) and the low RPR group (< 0.107). In the multivariable logistic regression model, high RPR (≥ 0.107) correlated with elevated risks of in-hospital mortality (OR 6.097, 95% CI [2.308-16.104], p < 0.001) and one-year mortality (OR 6.395, 95% CI [2.610-15.666], p < 0.001) after adjusting for all included covariates. Subgroup analyses revealed that high RPR consistently had increased risks of in-hospital mortality and one-year mortality. Besides, patients with low RPR show better one-year survival than those with high RPR.

Conclusion: Preoperative high RPR could serve as an independent risk predictor for in-hospital mortality and one-year mortality, which can be utilized to assess the prognosis of patients and further provide guidance for the treatment in patients following CABG.

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来源期刊

PeerJ MULTIDISCIPLINARY SCIENCES-

CiteScore

4.70

自引率

3.70%

发文量

1665

审稿时长

10 weeks

期刊介绍： PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.