比较Moderna的mRNA-1083和辉瑞的流感和COVID-19双靶点mRNA疫苗。

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-05-24 DOI:10.1038/s41541-025-01145-6

Adewunmi Akingbola, Abiodun Adegbesan, Kolade Adegoke, Courage Idahor, Petra Mariaria, Favour Peters, Raolat Adenike Salami, Olajide Ojo, Emmanuel Nwaeze, Owolabi Abdullahi, Joel Chuku

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引用次数: 0

摘要

本文综述了Moderna的mRNA-1083和辉瑞/BioNTech的mRNA-1020/1030新冠肺炎和流感双靶标疫苗。两者都利用mRNA技术，显示出强大的免疫原性和良好的安全性。Moderna的mRNA-1083表现出了更好的免疫应答，而辉瑞的mRNA-1020/1030表现良好，但对乙型流感的效果略差。这些疫苗简化了免疫策略，增强了保护作用，并强调了全球疫苗公平的必要性，以防止未来的疫情。

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Comparing Moderna's mRNA-1083 and Pfizer's dual-target mRNA vaccines for influenza and COVID-19.

This review examines Moderna's mRNA-1083 and Pfizer/BioNTech's mRNA-1020/1030 dual-target vaccines for COVID-19 and influenza. Both utilize mRNA technology, demonstrating strong immunogenicity and favorable safety profiles. Moderna's mRNA-1083 showed superior immune responses, while Pfizer's mRNA-1020/1030 performed well but was slightly less effective against influenza B. These vaccines simplify immunization strategies, enhance protection, and emphasize the need for global vaccine equity to prevent future outbreaks.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.