François Gabrielli, Melissa Zuel, Camille Magaud, Sophia Sickout-Arondo, Bruno Pereira, Jérémie Dassa, Solène De Gaalon, Geneviève Demarquay, Anne Donnet, Anne Ducros, Pierric Giraud, Evelyne Guégan-Massardier, Christian Lucas, Jérôme Mawet, Mitra Najjar, Caroline Roos, Elise K Van Obberghen, Christian Dualé, Radhouane Dallel, Xavier Moisset
{"title":"评估偏头痛相关感觉超敏反应(MHQ-8)的8项自填问卷的有效性","authors":"François Gabrielli, Melissa Zuel, Camille Magaud, Sophia Sickout-Arondo, Bruno Pereira, Jérémie Dassa, Solène De Gaalon, Geneviève Demarquay, Anne Donnet, Anne Ducros, Pierric Giraud, Evelyne Guégan-Massardier, Christian Lucas, Jérôme Mawet, Mitra Najjar, Caroline Roos, Elise K Van Obberghen, Christian Dualé, Radhouane Dallel, Xavier Moisset","doi":"10.1186/s10194-025-02067-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire.</p><p><strong>Methods: </strong>We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN's recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires.</p><p><strong>Results: </strong>The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach's alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021.</p><p><strong>Conclusions: </strong>The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"128"},"PeriodicalIF":7.3000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105241/pdf/","citationCount":"0","resultStr":"{\"title\":\"Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8).\",\"authors\":\"François Gabrielli, Melissa Zuel, Camille Magaud, Sophia Sickout-Arondo, Bruno Pereira, Jérémie Dassa, Solène De Gaalon, Geneviève Demarquay, Anne Donnet, Anne Ducros, Pierric Giraud, Evelyne Guégan-Massardier, Christian Lucas, Jérôme Mawet, Mitra Najjar, Caroline Roos, Elise K Van Obberghen, Christian Dualé, Radhouane Dallel, Xavier Moisset\",\"doi\":\"10.1186/s10194-025-02067-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire.</p><p><strong>Methods: </strong>We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN's recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires.</p><p><strong>Results: </strong>The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach's alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021.</p><p><strong>Conclusions: </strong>The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice.</p>\",\"PeriodicalId\":16013,\"journal\":{\"name\":\"Journal of Headache and Pain\",\"volume\":\"26 1\",\"pages\":\"128\"},\"PeriodicalIF\":7.3000,\"publicationDate\":\"2025-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105241/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Headache and Pain\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s10194-025-02067-3\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Headache and Pain","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s10194-025-02067-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8).
Background: In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire.
Methods: We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN's recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires.
Results: The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach's alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021.
Conclusions: The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice.
期刊介绍:
The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data.
With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.