Jacobo Mintzer, Rebecca Long, Arianne Fritts, Jane Joseph, Paul J Nietert, Noam Calev, Olga Brawman-Mintzer
{"title":"阿尔茨海默病患者脑叶的音乐参与研究（旋律）：一项随机对照试验。","authors":"Jacobo Mintzer, Rebecca Long, Arianne Fritts, Jane Joseph, Paul J Nietert, Noam Calev, Olga Brawman-Mintzer","doi":"10.1016/j.inpsyc.2025.100087","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effect of music exposure on global clinical impact, arousal, and brain network connectivity in subjects with moderate to severe Alzheimer's disease (AD).</p><p><strong>Design: </strong>This was a pilot, controlled, single-blind, randomized, cross-over study.</p><p><strong>Setting: </strong>The University Hospital Outpatient Clinic and Imaging Center and the Veterans Administration Research Facility.</p><p><strong>Participants: </strong>Ten participants aged between 55 and 90 years with moderate to severe AD, a Mini-Mental State Examination (MMSE) score of 5-20, and without neuropsychiatric symptoms of dementia were enrolled in the study.</p><p><strong>Intervention: </strong>Participants were exposed to both preferred music (PM) and nature sounds (NS). A randomization program was used to determine assignment order for either PM or NS to be delivered via over-ear headphones at Visit 1. Visit 2, which occurred approximately one week later, was identical to Visit 1, but the participants who were originally exposed to PM were exposed to NS and vice versa.</p><p><strong>Measurements: </strong>A modified version of the Alzheimer's Disease Cooperative Study Clinical Global Impression of Change (ADCS-CGIC) was the primary outcome measure and functional magnetic resonance imaging (fMRI) scans were used to evaluate brain network connectivity.</p><p><strong>Results: </strong>There was a clinically and statistically significant positive response to music stimulation in the primary outcome measure and in the secondary outcome measure, as well as a clear differentiation in brain network connectivity when individuals were exposed to PM versus NS. There was also a strong correlation between clinical changes and brain network connectivity changes as documented by fMRI.</p><p><strong>Conclusions: </strong>Music has the potential to be utilized as a non-invasive method to stimulate the brain of individuals with severe cognitive impairment in key functions TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov (ID: NCT05309369) by Jacobo Mintzer, MD, MBA.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100087"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Musical Engagement of brain LObes in Alzheimer's Disease patients study (MELODY): A randomized controlled trial.\",\"authors\":\"Jacobo Mintzer, Rebecca Long, Arianne Fritts, Jane Joseph, Paul J Nietert, Noam Calev, Olga Brawman-Mintzer\",\"doi\":\"10.1016/j.inpsyc.2025.100087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study evaluated the effect of music exposure on global clinical impact, arousal, and brain network connectivity in subjects with moderate to severe Alzheimer's disease (AD).</p><p><strong>Design: </strong>This was a pilot, controlled, single-blind, randomized, cross-over study.</p><p><strong>Setting: </strong>The University Hospital Outpatient Clinic and Imaging Center and the Veterans Administration Research Facility.</p><p><strong>Participants: </strong>Ten participants aged between 55 and 90 years with moderate to severe AD, a Mini-Mental State Examination (MMSE) score of 5-20, and without neuropsychiatric symptoms of dementia were enrolled in the study.</p><p><strong>Intervention: </strong>Participants were exposed to both preferred music (PM) and nature sounds (NS). A randomization program was used to determine assignment order for either PM or NS to be delivered via over-ear headphones at Visit 1. Visit 2, which occurred approximately one week later, was identical to Visit 1, but the participants who were originally exposed to PM were exposed to NS and vice versa.</p><p><strong>Measurements: </strong>A modified version of the Alzheimer's Disease Cooperative Study Clinical Global Impression of Change (ADCS-CGIC) was the primary outcome measure and functional magnetic resonance imaging (fMRI) scans were used to evaluate brain network connectivity.</p><p><strong>Results: </strong>There was a clinically and statistically significant positive response to music stimulation in the primary outcome measure and in the secondary outcome measure, as well as a clear differentiation in brain network connectivity when individuals were exposed to PM versus NS. There was also a strong correlation between clinical changes and brain network connectivity changes as documented by fMRI.</p><p><strong>Conclusions: </strong>Music has the potential to be utilized as a non-invasive method to stimulate the brain of individuals with severe cognitive impairment in key functions TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov (ID: NCT05309369) by Jacobo Mintzer, MD, MBA.</p>\",\"PeriodicalId\":14368,\"journal\":{\"name\":\"International psychogeriatrics\",\"volume\":\" \",\"pages\":\"100087\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International psychogeriatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.inpsyc.2025.100087\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International psychogeriatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.inpsyc.2025.100087","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Musical Engagement of brain LObes in Alzheimer's Disease patients study (MELODY): A randomized controlled trial.
Objectives: This study evaluated the effect of music exposure on global clinical impact, arousal, and brain network connectivity in subjects with moderate to severe Alzheimer's disease (AD).
Design: This was a pilot, controlled, single-blind, randomized, cross-over study.
Setting: The University Hospital Outpatient Clinic and Imaging Center and the Veterans Administration Research Facility.
Participants: Ten participants aged between 55 and 90 years with moderate to severe AD, a Mini-Mental State Examination (MMSE) score of 5-20, and without neuropsychiatric symptoms of dementia were enrolled in the study.
Intervention: Participants were exposed to both preferred music (PM) and nature sounds (NS). A randomization program was used to determine assignment order for either PM or NS to be delivered via over-ear headphones at Visit 1. Visit 2, which occurred approximately one week later, was identical to Visit 1, but the participants who were originally exposed to PM were exposed to NS and vice versa.
Measurements: A modified version of the Alzheimer's Disease Cooperative Study Clinical Global Impression of Change (ADCS-CGIC) was the primary outcome measure and functional magnetic resonance imaging (fMRI) scans were used to evaluate brain network connectivity.
Results: There was a clinically and statistically significant positive response to music stimulation in the primary outcome measure and in the secondary outcome measure, as well as a clear differentiation in brain network connectivity when individuals were exposed to PM versus NS. There was also a strong correlation between clinical changes and brain network connectivity changes as documented by fMRI.
Conclusions: Music has the potential to be utilized as a non-invasive method to stimulate the brain of individuals with severe cognitive impairment in key functions TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov (ID: NCT05309369) by Jacobo Mintzer, MD, MBA.
期刊介绍：
A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.
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