Mayssa Hachem, Abdelmoneim H Ali, Mariam Hejou, Aliyaa Almansoori, Shamma Abulhassan, Fatimah Hussein, Rana Khalifa, Rayan Khalifa, Peter R Corridon
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Sustainable and biotechnological production of docosahexaenoic acid from marine protists and slaughterhouse waste.
Docosahexaenoic acid (DHA, 22:6n-3) is an essential omega-3 polyunsaturated fatty acid, abundant in the brain and eyes. DHA is crucial for maintaining the structural integrity and physiological functions of these vital organs. Within the brain, DHA is concentrated in the gray matter, synaptic membranes, and hippocampus. Likewise, in the eyes, substantial quantities can be found in the retina, with lower levels in the cornea and lens. Previous studies have outlined the potential for culturing marine heterotrophic protists in ways that provide cost-effective and sustainable DHA biosynthesis. Similarly, our previous work on repurposing slaughterhouse waste has highlighted this underutilized source of brain and ocular tissue, which can support the extraction of valuable nutrients such as DHA. In this review, we will examine the current state of the art related to DHA production from these two sources, explore potential applications, and outline the possible benefits that may be generated from our approaches, with an emphasis on ocular diseases.
期刊介绍：
Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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