蛋白质和总糖摄入量调节rs9939609单核苷酸多态性对脂肪量和肥胖相关基因对身体组成的影响。

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-05-23 DOI:10.1016/j.clnesp.2025.05.032

Luciana Olmedo , Fernando Javier Luna , Hernán Dopazo , Magalí Pellon-Maison

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引用次数: 0

摘要

背景与目的：脂肪质量与肥胖相关基因（FTO） rs9939609单核苷酸多态性（SNP）的A等位基因与较高的体重指数（BMI）有关。尽管如此，一些环境因素可能会调节这种影响。本研究旨在发现基因-营养素对BMI、内脏脂肪（VF）、骨骼肌（SM）和体脂（BF）的相互作用。方法：数据是从横断面调查中获得的，对阿根廷成年男女进行调查。通过生物电阻抗分析收集体成分测量数据，通过食物频率问卷收集饮食变量，通过实时聚合酶链反应（qPCR）收集遗传数据。采用多元线性回归评估每等位基因对体组成的影响，采用协方差分析（ANCOVA）发现基因与饮食的相互作用。结果：轻度A变异增加BMI （1.4 kg/m2 [0.50-2.2], p=0.002）、BF （2.5% [0.8-4.2], p= 0.004）、VF(0.7任意单位[0.09-1.4],p= 0.026)，降低SM （1.5% [-2.5, 0.6], p= 0.009）。BMI的蛋白质摄入量（ηp2=0.051, p=0.027）和VF (ηp2=0.069, p=0.005)， BMI的总糖摄入量（ηp2=0.051, p=0.026）， BF的总糖摄入量（ηp2= 0.062, p=0.01）和VF的总糖摄入量（ηp2= 0.053, p=0.018）， SM的饱和脂肪酸摄入量（ηp2=0.056, p=0.018），基因与营养相互作用项均有统计学意义。同样，“牛奶和酸奶”（ηp2=0.052, p=0.041）和“肉和蛋”（ηp2=0.039, p=0.049）在BMI和“肉和蛋”（ηp2=0.069, p=0.006）和“水果”（ηp2= 0.054, p= 0.013）在VF上存在相互作用。结论：A等位基因参与机体组成变异，饮食调节其作用。

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Protein and total sugars intake modulate the rs9939609 single nucleotide polymorphism effect at the fat mass and obesity-associated gene on body composition

Background and aims

The A allele of the rs9939609 single nucleotide polymorphism (SNP) at the fat mass and obesity-associated gene (FTO) has been linked to a higher body mass index (BMI). Still, some environmental factors could modulate this effect. This study aimed to find gene-nutrient interactions on BMI, visceral fat (VF), skeletal muscle (SM), and body fat (BF).

Methods

The data were obtained from a cross-sectional investigation performed on Argentinian adults of both sexes. Body composition measurements were collected by bioelectrical impedance analysis, dietary variables by a food frequency questionnaire, and genetic data by real-time polymerase chain reaction (qPCR). Multiple linear regression was used to assess the per-allele effect on body composition, and covariance (ANCOVA) analysis was used to find gene–diet interactions.

Results

The minor A variant increased BMI (1.4 kg/m² [0.50–2.2], p = 0.002), BF (2.5 % [0.8–4.2], p = 0.004), and VF (0.7 arbitrary units [0.09–1.4], p = 0.026) and decreased SM (1.5 % [-2.5, 0.6], p = 0.009). Gene∗nutrient interaction terms were statistically significant for protein intake on BMI (η_p² = 0.051, p = 0.027) and VF (η_p² = 0.069, p = 0.005), for total sugars intake on BMI (η_p^{2 =}0.051, p = 0.026), BF (η_p^{2 =}0.062, p = 0.01) and VF (η_p^{2 =}0.053, p = 0.018), and saturated fatty acids (SFA) intake on SM (η_p²⁼0.056, p = 0.018). Consistently, interactions were found for “milk and yogurt” (η_p² = 0.052, p = 0.041) and “meat and eggs” (η_p² = 0.039, p = 0.049) on BMI and for “meat and eggs” (η_p² = 0.069, p = 0.006) and “fruits” (η_p² = 0.054, p = 0.013) on VF.

Conclusion

The A allele contributes to body composition variability, and diet modulates its effect.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.