Mohammad Reza Dehghani, Mehdi Moeini, Mehdi Masoumi, Yousef Rezaei
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The rates of in-hospital mortality (8.8% vs. 8.6%), rehospitalization during follow- up (13.7% vs. 12.3%), and 90-day mortality (6.5% vs. 5.3%) were comparable between the patients with and without fQRS, respectively. In the meta-analysis, 9 studies in addition to our study reported outcomes, with a total of 2928 patients with a mean age of 53.8 years, and 1431 (48.9%) were males. The rate of fQRS was 0.31 (95% confidence interval [CI], 0.23-0.38; I<sup>2</sup> = 95.21%). In addition, the pooled proportion of in-hospital mortality reported by 5 studies was 0.31 (95% CI, 0.12-0.51; I<sup>2</sup> = 98.36). 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引用次数: 0
摘要
背景：新型冠状病毒病2019 （COVID-19）与危及生命的并发症有关。在大多数危重患者中也报告了与COVID-19相关的心电图变化。方法：在本研究中，我们旨在探讨碎片化QRS （fQRS）在COVID-19住院患者中的患病率及其预后价值。此外，我们对文献进行了系统回顾和荟萃分析，以评估fQRS对COVID-19患者预后的影响。结果：共310例患者，平均年龄65.7±14.5岁，随访3个月，其中139例（44.8%）心电图出现fQRS。住院死亡率（8.8% vs. 8.6%）、随访期间再住院率（13.7% vs. 12.3%）和90天死亡率（6.5% vs. 5.3%）在有和没有fQRS的患者之间分别具有可比性。在meta分析中，除了我们的研究外，还有9项研究报告了结果，共2928例患者，平均年龄53.8岁，其中1431例（48.9%）为男性。fQRS为0.31(95%可信区间[CI]， 0.23-0.38；I2 = 95.21%)。此外，5项研究报告的住院死亡率的合并比例为0.31 (95% CI, 0.12-0.51；I2 = 98.36)。有fQRS的患者住院死亡率高于无fQRS的患者(优势比，2.33；95% ci, 1.52-3.58；P = 0.0001；I2 = 74%)。结论：2019冠状病毒病患者心电图fQRS发生率较高，meta分析显示其与住院患者预后较差相关。
Prognostic Value of Fragmented QRS on Admission Electrocardiogram among Patients Hospitalized with COVID-19: A Single-Center Report, Systematic Review, and Meta-Analysis.
Background: The novel coronavirus disease 2019 (COVID-19) is associated with life-threatening complications. Electrocardiogram (ECG) changes associated with COVID-19 have also been reported in the majority of critically ill patients.
Methods: In this study, we aimed to investigate the prevalence of fragmented QRS (fQRS) and its prognostic value in hospitalized patients with COVID-19. In addition, we performed a systematic review and meta-analysis of the literature to evaluate the effect of fQRS on the outcomes of COVID-19 patients.
Results: A total of 310 patients with a mean age of 65.7 ± 14.5 years were followed up for 3 months, of whom 139 (44.8%) had fQRS on their ECGs. The rates of in-hospital mortality (8.8% vs. 8.6%), rehospitalization during follow- up (13.7% vs. 12.3%), and 90-day mortality (6.5% vs. 5.3%) were comparable between the patients with and without fQRS, respectively. In the meta-analysis, 9 studies in addition to our study reported outcomes, with a total of 2928 patients with a mean age of 53.8 years, and 1431 (48.9%) were males. The rate of fQRS was 0.31 (95% confidence interval [CI], 0.23-0.38; I2 = 95.21%). In addition, the pooled proportion of in-hospital mortality reported by 5 studies was 0.31 (95% CI, 0.12-0.51; I2 = 98.36). The rate of in-hospital mortality was higher among patients with fQRS compared to those without fQRS (odds ratio, 2.33; 95% CI, 1.52-3.58; p = 0.0001; I2 = 74%).
Conclusions: The rate of fQRS on ECG was relatively high in COVID-19 patients, and according to the meta-analysis, it was associated with worse outcomes in hospitalized COVID-19 patients.
期刊介绍：
Acta Cardiologica Sinica welcomes all the papers in the fields related to cardiovascular medicine including basic research, vascular biology, clinical pharmacology, clinical trial, critical care medicine, coronary artery disease, interventional cardiology, arrythmia and electrophysiology, atherosclerosis, hypertension, cardiomyopathy and heart failure, valvular and structure cardiac disease, pediatric cardiology, cardiovascular surgery, and so on. We received papers from more than 20 countries and areas of the world. Currently, 40% of the papers were submitted to Acta Cardiologica Sinica from Taiwan, 20% from China, and 20% from the other countries and areas in the world. The acceptance rate for publication was around 50% in general.
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