{"title":"偏头痛患者异常自发性低频脑活动：静息状态fMRI研究的荟萃分析","authors":"Qiuyi Chen, Yuhan Liu, Xin Yang, Bin Li, Lu Liu","doi":"10.1111/jon.70043","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Purpose</h3>\n \n <p>Resting-state functional MRI has revealed abnormal brain activity in patients with migraine, though findings have been inconsistent. This meta-analysis utilized Seed-based d Mapping to assess variations in amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF). The aim was to identify common brain regions with altered spontaneous brain activity in migraine patients.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic search was conducted in PubMed, Web of Science, and Embase for studies published up to August 2023, comparing spontaneous low-frequency brain activity between migraine patients and healthy controls (HCs). Jackknife sensitivity, heterogeneity, publication bias, and meta-regression analyses were performed to ensure the robustness and reliability of our findings.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Nine studies, including 708 migraine patients and HCs, were included in the analysis. Applying a highly conservative family-wise error rate correction, no significant findings were observed. However, when a less conservative threshold was used, migraine patients exhibited increased ALFF/fALFF in the left anterior thalamus and the corticospinal tract but showed decreased values in the right middle frontal gyrus. Jackknife sensitivity analysis confirmed the reproducibility of these results, while heterogeneity analysis revealed significant variability across studies, likely due to differences in study design and patient populations.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This meta-analysis provides a comprehensive synthesis of neuroimaging evidence, linking migraine to abnormal spontaneous brain activity in regions associated with pain processing and nociceptive emotional modulation. These findings enhance our understanding of migraine pathophysiology and highlight potential targets for neuromodulation therapies, offering new directions for future research and clinical interventions.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 3","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70043","citationCount":"0","resultStr":"{\"title\":\"Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies\",\"authors\":\"Qiuyi Chen, Yuhan Liu, Xin Yang, Bin Li, Lu Liu\",\"doi\":\"10.1111/jon.70043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background and Purpose</h3>\\n \\n <p>Resting-state functional MRI has revealed abnormal brain activity in patients with migraine, though findings have been inconsistent. 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引用次数: 0
摘要
背景和目的静息状态功能MRI显示偏头痛患者的大脑活动异常，尽管结果不一致。本荟萃分析利用基于种子的d映射来评估低频波动幅度（ALFF）和低频波动幅度分数（fALFF）的变化。目的是确定偏头痛患者大脑自发活动改变的共同大脑区域。方法系统检索PubMed、Web of Science和Embase截至2023年8月发表的研究，比较偏头痛患者和健康对照（hc）的自发低频脑活动。为了确保研究结果的稳健性和可靠性，我们进行了刀切敏感性、异质性、发表偏倚和meta回归分析。结果纳入9项研究，包括708例偏头痛患者和hc患者。应用高度保守的家庭误差率校正，没有观察到显著的发现。然而，当使用较低的保守阈值时，偏头痛患者表现出左前丘脑和皮质脊髓束的ALFF/fALFF增加，但右侧额叶中回的ALFF/fALFF值下降。Jackknife敏感性分析证实了这些结果的可重复性，而异质性分析显示了研究之间的显著差异，可能是由于研究设计和患者群体的差异。结论：本荟萃分析提供了综合的神经影像学证据，将偏头痛与疼痛加工和伤害性情绪调节相关区域的异常自发脑活动联系起来。这些发现增强了我们对偏头痛病理生理学的认识，突出了神经调节治疗的潜在靶点，为未来的研究和临床干预提供了新的方向。
Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies
Background and Purpose
Resting-state functional MRI has revealed abnormal brain activity in patients with migraine, though findings have been inconsistent. This meta-analysis utilized Seed-based d Mapping to assess variations in amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF). The aim was to identify common brain regions with altered spontaneous brain activity in migraine patients.
Methods
A systematic search was conducted in PubMed, Web of Science, and Embase for studies published up to August 2023, comparing spontaneous low-frequency brain activity between migraine patients and healthy controls (HCs). Jackknife sensitivity, heterogeneity, publication bias, and meta-regression analyses were performed to ensure the robustness and reliability of our findings.
Results
Nine studies, including 708 migraine patients and HCs, were included in the analysis. Applying a highly conservative family-wise error rate correction, no significant findings were observed. However, when a less conservative threshold was used, migraine patients exhibited increased ALFF/fALFF in the left anterior thalamus and the corticospinal tract but showed decreased values in the right middle frontal gyrus. Jackknife sensitivity analysis confirmed the reproducibility of these results, while heterogeneity analysis revealed significant variability across studies, likely due to differences in study design and patient populations.
Conclusions
This meta-analysis provides a comprehensive synthesis of neuroimaging evidence, linking migraine to abnormal spontaneous brain activity in regions associated with pain processing and nociceptive emotional modulation. These findings enhance our understanding of migraine pathophysiology and highlight potential targets for neuromodulation therapies, offering new directions for future research and clinical interventions.
期刊介绍：
Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on:
MRI
CT
Carotid Ultrasound and TCD
SPECT
PET
Endovascular Surgical Neuroradiology
Functional MRI
Xenon CT
and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!
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