Advances in the synthesis and biological functionality of pyrazolines and pyrazoles from chalcone precursors

The primary objective of this review is to outline the synthesis of pyrazolines and pyrazoles derived from 1,3-diaryl Prop-2-en-1-ones as crucial precursors and to elucidate their potential biological activities. The diverse synthetic methodologies, including 1,3-dielectrophile cyclization, 1,3-dipolar cycloaddition/1,3-H shift, Michael Addition reactions, [3+2] annulations, intramolecular condensation reactions, Atwal Reactions, and others, have been deliberated upon. Chalcones are considered important compounds because of their ketoethylenic group, and they include a wide array of compounds with various applications. The investigation of the biological evaluation of pyrazoline and pyrazole derivatives has emerged as a convincing area of research within pharmaceutical chemistry. This review may serve as a valuable resource for the development and design of novel, potent therapeutic agents, leveraging previously established strategies.