Abu Taher, Aporajita Das Trisha, Shamim Ahmed, Jannat Begum, Falguni Sinha, Nusrat Zaman Sarna, Nurshad Ali
{"title":"调查孟加拉年轻人血清尿酸与血脂异常的关系","authors":"Abu Taher, Aporajita Das Trisha, Shamim Ahmed, Jannat Begum, Falguni Sinha, Nusrat Zaman Sarna, Nurshad Ali","doi":"10.1002/edm2.70063","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (<i>p</i> < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (<i>p</i> < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (<i>p</i> < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male–female groups separately (at least <i>p</i> < 0.05). Furthermore, a significant association (<i>p</i> < 0.001) was found between SUA and individual lipid components in the regression models.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.</p>\n </section>\n </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70063","citationCount":"0","resultStr":"{\"title\":\"Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh\",\"authors\":\"Abu Taher, Aporajita Das Trisha, Shamim Ahmed, Jannat Begum, Falguni Sinha, Nusrat Zaman Sarna, Nurshad Ali\",\"doi\":\"10.1002/edm2.70063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (<i>p</i> < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (<i>p</i> < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (<i>p</i> < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male–female groups separately (at least <i>p</i> < 0.05). Furthermore, a significant association (<i>p</i> < 0.001) was found between SUA and individual lipid components in the regression models.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36522,\"journal\":{\"name\":\"Endocrinology, Diabetes and Metabolism\",\"volume\":\"8 3\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70063\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrinology, Diabetes and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/edm2.70063\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, Diabetes and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/edm2.70063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh
Objectives
While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.
Methods
This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.
Results
The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (p < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (p < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (p < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male–female groups separately (at least p < 0.05). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models.
Conclusion
Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.
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