脊髓损伤模型:病理生理学和临床意义上的优缺点

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Min-Qi Li , Qing-Hua Wang , Chuan-Ming Dong , Long-Ju Qi
{"title":"脊髓损伤模型:病理生理学和临床意义上的优缺点","authors":"Min-Qi Li ,&nbsp;Qing-Hua Wang ,&nbsp;Chuan-Ming Dong ,&nbsp;Long-Ju Qi","doi":"10.1016/j.bbrep.2025.102063","DOIUrl":null,"url":null,"abstract":"<div><div>Over recent decades, SCI research has advanced in understanding its pathophysiology and related mechanisms. Researchers developed many rodent SCI models to mimic injury processes, which are crucial for evaluating therapies and understanding pathology. But choosing the right model for specific research is challenging due to distinct pathological changes. This review overviews SCI pathophysiology and examines rodent models. It emphasizes model - related challenges, application value, simulation degrees, and replication of pathologies. It also discusses model advantages and limitations, and references recent reverse-engineering projects, which provide a brand-new perspective for promoting SCI research.</div></div>","PeriodicalId":8771,"journal":{"name":"Biochemistry and Biophysics Reports","volume":"42 ","pages":"Article 102063"},"PeriodicalIF":2.2000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spinal cord injury models: Advantages and disadvantages in the view of pathophysiology and clinical significance\",\"authors\":\"Min-Qi Li ,&nbsp;Qing-Hua Wang ,&nbsp;Chuan-Ming Dong ,&nbsp;Long-Ju Qi\",\"doi\":\"10.1016/j.bbrep.2025.102063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Over recent decades, SCI research has advanced in understanding its pathophysiology and related mechanisms. Researchers developed many rodent SCI models to mimic injury processes, which are crucial for evaluating therapies and understanding pathology. But choosing the right model for specific research is challenging due to distinct pathological changes. This review overviews SCI pathophysiology and examines rodent models. It emphasizes model - related challenges, application value, simulation degrees, and replication of pathologies. It also discusses model advantages and limitations, and references recent reverse-engineering projects, which provide a brand-new perspective for promoting SCI research.</div></div>\",\"PeriodicalId\":8771,\"journal\":{\"name\":\"Biochemistry and Biophysics Reports\",\"volume\":\"42 \",\"pages\":\"Article 102063\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry and Biophysics Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405580825001505\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry and Biophysics Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405580825001505","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

近几十年来,脊髓损伤的研究在病理生理学和相关机制方面取得了进展。研究人员开发了许多啮齿类动物脊髓损伤模型来模拟损伤过程,这对于评估治疗和理解病理学至关重要。但是,由于不同的病理变化,为特定的研究选择正确的模型是具有挑战性的。本文综述了脊髓损伤的病理生理学和啮齿动物模型。它强调与模型相关的挑战、应用价值、模拟程度和病理的复制。讨论了模型的优点和局限性,并参考了最近的逆向工程项目,为促进SCI研究提供了全新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spinal cord injury models: Advantages and disadvantages in the view of pathophysiology and clinical significance
Over recent decades, SCI research has advanced in understanding its pathophysiology and related mechanisms. Researchers developed many rodent SCI models to mimic injury processes, which are crucial for evaluating therapies and understanding pathology. But choosing the right model for specific research is challenging due to distinct pathological changes. This review overviews SCI pathophysiology and examines rodent models. It emphasizes model - related challenges, application value, simulation degrees, and replication of pathologies. It also discusses model advantages and limitations, and references recent reverse-engineering projects, which provide a brand-new perspective for promoting SCI research.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
191
审稿时长
59 days
期刊介绍: Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信