氯胺酮对进食障碍患者的高级护理治疗安全吗?亚麻醉氯胺酮104例安全性分析

IF 3.7 2区 医学 Q1 PSYCHIATRY
Elizabeth Wassenaar , Dan V. Blalock , Alan Duffy , Megan Riddle , Howard Weeks , Phil Mehler , Renee D. Rienecke
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引用次数: 0

摘要

饮食失调是最具挑战性和最致命的精神疾病之一,由于营养不良或其他饮食失调行为引起的医疗不稳定并发症,对同时患有抑郁症和情绪障碍的患者构成了独特的治疗挑战。随机对照试验已经证明,通用氯胺酮对难治性抑郁症和双相抑郁症患者有“快速而有力的抗抑郁作用”。本文评估了氯胺酮作为治疗共存的难治性抑郁症或双相抑郁症的医疗安全性,这些患者因饮食失调而受到更高水平的护理。对104名因饮食失调而接受更高水平护理的患者进行了回顾性分析,这些患者同时患有难治性抑郁症或双相情感障碍。收集和分析了关于医疗安全的数据,特别是在医疗和营养不稳定的情况下。研究结果表明,氯胺酮是一种安全的干预措施,适用于饮食失调和同时出现难治性抑郁症或双相抑郁症的患者,即使是在因饮食失调行为而出现相对的医疗或营养不稳定的情况下。本文提出氯胺酮可以在医学监测下安全地用于同时发生进食障碍和治疗难治性抑郁症或双相抑郁症的患者,尽管这类患者的医疗和营养不稳定带来了挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is ketamine safe for individuals in higher level of care treatment for eating disorders? Analysis of safety of subanesthetic ketamine in 104 patients
Eating disorders are among the most challenging and fatal mental illnesses and, due to the complication of medical instability caused by malnutrition or other disordered eating behaviors, pose unique treatment challenges for patients with co-occurring depression and mood disorders. Randomized control trials have demonstrated “rapid and robust antidepressant effects” of generic ketamine in individuals with treatment-resistant depression and bipolar depression. This paper assesses the medical safety of ketamine as a treatment for co-occurring treatment-resistant depression or bipolar depression in patients in higher levels of care for their eating disorders. A retrospective analysis was conducted on 104 patients receiving higher levels of care for their eating disorder and who had co-occurring treatment-resistant depression or bipolar disorder. Data on medical safety, particularly in the context of medical and nutritional instability, was collected and analyzed. The findings demonstrated that ketamine is a safe intervention for patients with eating disorders and co-occurring treatment-resistant depression or bipolar depression, even in cases where relative medical or nutritional instability was present due to disordered eating behaviors. This paper presents that ketamine can be used safely with medical monitoring in patents with co-occurring eating disorder and treatment-resistant depression or bipolar depression, despite the challenges posed by medical and nutritional instability in this patient population.
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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