{"title":"7月龄女性真菌性败血症:通过外周血涂片诊断","authors":"Yihun Bedaso , Tadesse Alemayehu , Amanuel Anegagregn Bizuneh , Dereje Zeleke Haile , Seble Seifu Zeleke , Mekdes Shifeta , Agete Tadewos Hirigo","doi":"10.1016/j.mmcr.2025.100708","DOIUrl":null,"url":null,"abstract":"<div><div>We report a case of a 7-month-old female with prolonged high-grade fever unresponsive to broad-spectrum antibiotics and antimalarial drugs. Despite negative cultures and imaging, a Giemsa-stained peripheral blood smear on day 28 revealed yeast cells, suggesting fungal sepsis in the context of prolonged antibiotic exposure and thrombocytopenia. The patient responded well to oral fluconazole, with full clinical recovery. This case underscores the value of peripheral blood smear examination in diagnosing yeast infections in resource-limited settings.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100708"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fungal sepsis in a 7-month-old female: diagnosis through peripheral blood smear\",\"authors\":\"Yihun Bedaso , Tadesse Alemayehu , Amanuel Anegagregn Bizuneh , Dereje Zeleke Haile , Seble Seifu Zeleke , Mekdes Shifeta , Agete Tadewos Hirigo\",\"doi\":\"10.1016/j.mmcr.2025.100708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>We report a case of a 7-month-old female with prolonged high-grade fever unresponsive to broad-spectrum antibiotics and antimalarial drugs. Despite negative cultures and imaging, a Giemsa-stained peripheral blood smear on day 28 revealed yeast cells, suggesting fungal sepsis in the context of prolonged antibiotic exposure and thrombocytopenia. The patient responded well to oral fluconazole, with full clinical recovery. This case underscores the value of peripheral blood smear examination in diagnosing yeast infections in resource-limited settings.</div></div>\",\"PeriodicalId\":51724,\"journal\":{\"name\":\"Medical Mycology Case Reports\",\"volume\":\"48 \",\"pages\":\"Article 100708\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Mycology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221175392500017X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Mycology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221175392500017X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Fungal sepsis in a 7-month-old female: diagnosis through peripheral blood smear
We report a case of a 7-month-old female with prolonged high-grade fever unresponsive to broad-spectrum antibiotics and antimalarial drugs. Despite negative cultures and imaging, a Giemsa-stained peripheral blood smear on day 28 revealed yeast cells, suggesting fungal sepsis in the context of prolonged antibiotic exposure and thrombocytopenia. The patient responded well to oral fluconazole, with full clinical recovery. This case underscores the value of peripheral blood smear examination in diagnosing yeast infections in resource-limited settings.